Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice

Endogenous opioid and nociceptin systems are widely distributed in the gastrointestinal tract where they seem to play a crucial role in maintaining the intestinal homeostasis. The aim of our study was to assess whether activation of nociceptin (NOP) and µ-opioid (MOP) receptors by a mixed NOP/MOP re...

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Veröffentlicht in:	European journal of pharmacology 2015-10, Vol.765, p.582-590
Hauptverfasser:	Zielińska, Marta, Haddou, Tanila Ben, Cami-Kobeci, Gerta, Sałaga, Maciej, Jarmuż, Agata, Padysz, Milena, Kordek, Radzisław, Spetea, Mariana, Husbands, Stephen M., Fichna, Jakub
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Buprenorphine - analogs & derivatives Buprenorphine - pharmacology Buprenorphine - therapeutic use Cell Line Colitis - chemically induced Colitis - drug therapy Colitis - metabolism Crohn's disease Dose-Response Relationship, Drug Humans Inflammatory bowel diseases Male Mice Mice, Inbred BALB C Mixed opioid agonists Receptors, Opioid - agonists Receptors, Opioid - metabolism Treatment Outcome Trinitrobenzenesulfonic Acid - toxicity Visceral pain
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