FOXA and master transcription factors recruit Mediator and Cohesin to the core transcriptional regulatory circuitry of cancer cells

Controlling the transcriptional program is essential to maintain the identity and the biological functions of a cell. The Mediator and Cohesin complexes have been established as central cofactors controlling the transcriptional program in normal cells. However, the distribution, recruitment and impo...

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Veröffentlicht in:	Scientific reports 2016-10, Vol.6 (1), p.34962-34962, Article 34962
Hauptverfasser:	Fournier, Michèle, Bourriquen, Gaëlle, Lamaze, Fabien C., Côté, Maxime C., Fournier, Éric, Joly-Beauparlant, Charles, Caron, Vicky, Gobeil, Stéphane, Droit, Arnaud, Bilodeau, Steve
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/89 38/23 631/1647/48 631/337/572/2102 A549 Cells Cancer Cell Cycle Proteins - metabolism Cell Proliferation Chromatin Immunoprecipitation Chromosomal Proteins, Non-Histone - metabolism Cofactors Cohesin Cohesins Enhancer Elements, Genetic Gene Expression Regulation, Neoplastic Hep G2 Cells Hepatocyte Nuclear Factor 3-alpha - metabolism Humanities and Social Sciences Humans Integration MCF-7 Cells Mediator Complex - metabolism multidisciplinary Neoplasms - metabolism Principal Component Analysis Promoter Regions, Genetic Regulatory sequences Science Transcription factors Transcription, Genetic
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