Arterial Effects of Canakinumab in Patients With Atherosclerosis and Type 2 Diabetes or Glucose Intolerance

Abstract Background Evidence suggests that interleukin (IL)-1β is important in the pathogenesis of atherosclerosis and its complications and that inhibiting IL-1β may favorably affect vascular disease progression. Objectives The goal of this study was to evaluate the effects of IL-1β inhibition with...

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Veröffentlicht in:	Journal of the American College of Cardiology 2016-10, Vol.68 (16), p.1769-1780
Hauptverfasser:	Choudhury, Robin P., DM, Birks, Jacqueline S., MSc, Mani, Venkatesh, PhD, Biasiolli, Luca, PhD, Robson, Matthew D., PhD, L'Allier, Philippe L., MD, Gingras, Marc-Alexandre, Alie, Nadia, BS, McLaughlin, Mary Ann, MD, Basson, Craig T., MD, PhD, Schecter, Alison D., MD, Svensson, Eric C., MD, PhD, Zhang, Yiming, PhD, Yates, Denise, PhD, Tardif, Jean-Claude, MD, Fayad, Zahi A., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Arteries - drug effects Atherosclerosis Atherosclerosis - complications Atherosclerosis - drug therapy C-reactive protein Cardiology Cardiovascular Cytokines Diabetes Diabetes Mellitus, Type 2 - complications Double-Blind Method Female Glucose Glucose Intolerance - complications Heart attacks homeostasis model assessment Humans Inflammation interleukin-1 Interleukin-1beta - antagonists & inhibitors Internal Medicine Male Middle Aged Mortality NMR Nuclear magnetic resonance Original Investigation Patients Proteins
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