Receptor Activity-modifying Protein-directed G Protein Signaling Specificity for the Calcitonin Gene-related Peptide Family of Receptors

The calcitonin gene-related peptide (CGRP) family of G protein-coupled receptors (GPCRs) is formed through the association of the calcitonin receptor-like receptor (CLR) and one of three receptor activity-modifying proteins (RAMPs). Binding of one of the three peptide ligands, CGRP, adrenomedullin (...

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Veröffentlicht in:	The Journal of biological chemistry 2016-10, Vol.291 (42), p.21925-21944
Hauptverfasser:	Weston, Cathryn, Winfield, Ian, Harris, Matthew, Hodgson, Rose, Shah, Archna, Dowell, Simon J, Mobarec, Juan Carlos, Woodlock, David A, Reynolds, Christopher A, Poyner, David R, Watkins, Harriet A, Ladds, Graham
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin - genetics Adrenomedullin - metabolism Cyclic AMP - genetics Cyclic AMP - metabolism GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits - metabolism HEK293 Cells Humans Nuclear Proteins - genetics Nuclear Proteins - metabolism Receptors, Calcitonin Gene-Related Peptide - genetics Receptors, Calcitonin Gene-Related Peptide - metabolism Second Messenger Systems - physiology Signal Transduction
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