Molecular profiling of head and neck squamous cell carcinoma

Background Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of recurrence, and with few approved targeted agents, novel treatments are needed. We analyzed a molecular profiling database for the distribution of biomarkers predictive of chemotherapies and targeted agents. Methods Seve...

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Veröffentlicht in:	Head & neck 2016-04, Vol.38 (S1), p.E1625-E1638
Hauptverfasser:	Feldman, Rebecca, Gatalica, Zoran, Knezetic, Joseph, Reddy, Sandeep, Nathan, Cherie-Ann, Javadi, Nader, Teknos, Theodoros
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over B7-H1 Antigen - genetics biomarkers Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Class I Phosphatidylinositol 3-Kinases - genetics DNA sequencing Female Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - genetics head and neck squamous cell carcinoma Humans Male Middle Aged molecular profiling Mutation Neoplasm Recurrence, Local Original Papillomaviridae Papillomavirus Infections Programmed Cell Death 1 Receptor - genetics protein expression PTEN Phosphohydrolase - genetics Receptor, Epidermal Growth Factor - genetics Tumor Suppressor Protein p53 - genetics Young Adult
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