Molecular profiling of head and neck squamous cell carcinoma
Background Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of recurrence, and with few approved targeted agents, novel treatments are needed. We analyzed a molecular profiling database for the distribution of biomarkers predictive of chemotherapies and targeted agents. Methods Seve...
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| Veröffentlicht in: | Head & neck 2016-04, Vol.38 (S1), p.E1625-E1638 |
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| creator | Feldman, Rebecca Gatalica, Zoran Knezetic, Joseph Reddy, Sandeep Nathan, Cherie-Ann Javadi, Nader Teknos, Theodoros |
| description | Background
Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of recurrence, and with few approved targeted agents, novel treatments are needed. We analyzed a molecular profiling database for the distribution of biomarkers predictive of chemotherapies and targeted agents.
Methods
Seven hundred thirty‐five patients with advanced HNSCC (88 with known human papillomavirus [HPV] status), were profiled using multiple platforms (gene sequencing, gene copy number, and protein expression).
Results
Among the entire patient population studied, epidermal growth factor receptor (EGFR) was the protein most often overexpressed (90%), TP53 gene most often mutated (41%), and phosphatidylinositol 3‐kinase (PIK3CA) most often amplified (40%; n = 5). With the exception of TP53 mutation, other biomarker frequencies were not significantly different among HPV‐positive or HPV‐negative patients. PIK3CA mutations and phosphatase and tensin homolog (PTEN) loss are frequent events, independent of HPV status. The immune response‐modulating programmed cell death 1 (PD1) and programmed cell death ligand 1 (PDL1) axis was active across sites, stages, and HPV status.
Conclusion
Molecular profiling utilizing multiple platforms provides a range of therapy options beyond standard of care. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1625–E1638, 2016 |
| doi_str_mv | 10.1002/hed.24290 |
| format | Article |
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Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of recurrence, and with few approved targeted agents, novel treatments are needed. We analyzed a molecular profiling database for the distribution of biomarkers predictive of chemotherapies and targeted agents.
Methods
Seven hundred thirty‐five patients with advanced HNSCC (88 with known human papillomavirus [HPV] status), were profiled using multiple platforms (gene sequencing, gene copy number, and protein expression).
Results
Among the entire patient population studied, epidermal growth factor receptor (EGFR) was the protein most often overexpressed (90%), TP53 gene most often mutated (41%), and phosphatidylinositol 3‐kinase (PIK3CA) most often amplified (40%; n = 5). With the exception of TP53 mutation, other biomarker frequencies were not significantly different among HPV‐positive or HPV‐negative patients. PIK3CA mutations and phosphatase and tensin homolog (PTEN) loss are frequent events, independent of HPV status. The immune response‐modulating programmed cell death 1 (PD1) and programmed cell death ligand 1 (PDL1) axis was active across sites, stages, and HPV status.
Conclusion
Molecular profiling utilizing multiple platforms provides a range of therapy options beyond standard of care. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1625–E1638, 2016</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.24290</identifier><identifier>PMID: 26614708</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; B7-H1 Antigen - genetics ; biomarkers ; Biomarkers, Tumor - genetics ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - genetics ; Class I Phosphatidylinositol 3-Kinases - genetics ; DNA sequencing ; Female ; Head and Neck Neoplasms - diagnosis ; Head and Neck Neoplasms - genetics ; head and neck squamous cell carcinoma ; Humans ; Male ; Middle Aged ; molecular profiling ; Mutation ; Neoplasm Recurrence, Local ; Original ; Papillomaviridae ; Papillomavirus Infections ; Programmed Cell Death 1 Receptor - genetics ; protein expression ; PTEN Phosphohydrolase - genetics ; Receptor, Epidermal Growth Factor - genetics ; Tumor Suppressor Protein p53 - genetics ; Young Adult</subject><ispartof>Head & neck, 2016-04, Vol.38 (S1), p.E1625-E1638</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5190-235df34a62fe0c65b203a279472a5b60d7a486cfbb148371272d9292e69ea2e83</citedby><cites>FETCH-LOGICAL-c5190-235df34a62fe0c65b203a279472a5b60d7a486cfbb148371272d9292e69ea2e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.24290$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.24290$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26614708$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feldman, Rebecca</creatorcontrib><creatorcontrib>Gatalica, Zoran</creatorcontrib><creatorcontrib>Knezetic, Joseph</creatorcontrib><creatorcontrib>Reddy, Sandeep</creatorcontrib><creatorcontrib>Nathan, Cherie-Ann</creatorcontrib><creatorcontrib>Javadi, Nader</creatorcontrib><creatorcontrib>Teknos, Theodoros</creatorcontrib><title>Molecular profiling of head and neck squamous cell carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of recurrence, and with few approved targeted agents, novel treatments are needed. We analyzed a molecular profiling database for the distribution of biomarkers predictive of chemotherapies and targeted agents.
Methods
Seven hundred thirty‐five patients with advanced HNSCC (88 with known human papillomavirus [HPV] status), were profiled using multiple platforms (gene sequencing, gene copy number, and protein expression).
Results
Among the entire patient population studied, epidermal growth factor receptor (EGFR) was the protein most often overexpressed (90%), TP53 gene most often mutated (41%), and phosphatidylinositol 3‐kinase (PIK3CA) most often amplified (40%; n = 5). With the exception of TP53 mutation, other biomarker frequencies were not significantly different among HPV‐positive or HPV‐negative patients. PIK3CA mutations and phosphatase and tensin homolog (PTEN) loss are frequent events, independent of HPV status. The immune response‐modulating programmed cell death 1 (PD1) and programmed cell death ligand 1 (PDL1) axis was active across sites, stages, and HPV status.
Conclusion
Molecular profiling utilizing multiple platforms provides a range of therapy options beyond standard of care. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1625–E1638, 2016</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>B7-H1 Antigen - genetics</subject><subject>biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Class I Phosphatidylinositol 3-Kinases - genetics</subject><subject>DNA sequencing</subject><subject>Female</subject><subject>Head and Neck Neoplasms - diagnosis</subject><subject>Head and Neck Neoplasms - genetics</subject><subject>head and neck squamous cell carcinoma</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>molecular profiling</subject><subject>Mutation</subject><subject>Neoplasm Recurrence, Local</subject><subject>Original</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections</subject><subject>Programmed Cell Death 1 Receptor - genetics</subject><subject>protein expression</subject><subject>PTEN Phosphohydrolase - genetics</subject><subject>Receptor, Epidermal Growth Factor - genetics</subject><subject>Tumor Suppressor Protein p53 - genetics</subject><subject>Young Adult</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi0EakvpgT9Q5QiHtOOP2IlUIUEpLai0hy4fN2viTLqmSby1N0D_Pdluu4IDJ4_kZ56ZeRl7yeGAA4jDOTUHQokKnrAdDpXJQSrzdFUrmUswaps9T-kHAEitxBbbFlpzZaDcYUefQ0du7DBmixha3_nhOgttNidsMhyabCB3k6XbEfswpsxR12UOo_ND6PEFe9Zil2jv4d1lXz6czI7P8vPL04_Hb89zV_AKciGLppUKtWgJnC5qARKFqZQRWNQaGoOq1K6ta65KabgwoqlEJUhXhIJKucverL2Lse6pcTQsI3Z2EX2P8c4G9Pbfn8HP7XX4aQvQkhuYBK8eBDHcjpSWtvdpdQsONJ1luSmVUbqSK_T1GnUxpBSp3YzhYFdp2ylte5_2xO7_vdeGfIx3Ag7XwC_f0d3_Tfbs5P2jMl93-LSk35sOjDdWG2kK--3i1H4tZp_efeczeyX_ALJnl-w</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Feldman, Rebecca</creator><creator>Gatalica, Zoran</creator><creator>Knezetic, Joseph</creator><creator>Reddy, Sandeep</creator><creator>Nathan, Cherie-Ann</creator><creator>Javadi, Nader</creator><creator>Teknos, Theodoros</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>BSCLL</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201604</creationdate><title>Molecular profiling of head and neck squamous cell carcinoma</title><author>Feldman, Rebecca ; Gatalica, Zoran ; Knezetic, Joseph ; Reddy, Sandeep ; Nathan, Cherie-Ann ; Javadi, Nader ; Teknos, Theodoros</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5190-235df34a62fe0c65b203a279472a5b60d7a486cfbb148371272d9292e69ea2e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>B7-H1 Antigen - genetics</topic><topic>biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Class I Phosphatidylinositol 3-Kinases - genetics</topic><topic>DNA sequencing</topic><topic>Female</topic><topic>Head and Neck Neoplasms - diagnosis</topic><topic>Head and Neck Neoplasms - genetics</topic><topic>head and neck squamous cell carcinoma</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>molecular profiling</topic><topic>Mutation</topic><topic>Neoplasm Recurrence, Local</topic><topic>Original</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections</topic><topic>Programmed Cell Death 1 Receptor - genetics</topic><topic>protein expression</topic><topic>PTEN Phosphohydrolase - genetics</topic><topic>Receptor, Epidermal Growth Factor - genetics</topic><topic>Tumor Suppressor Protein p53 - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feldman, Rebecca</creatorcontrib><creatorcontrib>Gatalica, Zoran</creatorcontrib><creatorcontrib>Knezetic, Joseph</creatorcontrib><creatorcontrib>Reddy, Sandeep</creatorcontrib><creatorcontrib>Nathan, Cherie-Ann</creatorcontrib><creatorcontrib>Javadi, Nader</creatorcontrib><creatorcontrib>Teknos, Theodoros</creatorcontrib><collection>Istex</collection><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feldman, Rebecca</au><au>Gatalica, Zoran</au><au>Knezetic, Joseph</au><au>Reddy, Sandeep</au><au>Nathan, Cherie-Ann</au><au>Javadi, Nader</au><au>Teknos, Theodoros</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular profiling of head and neck squamous cell carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2016-04</date><risdate>2016</risdate><volume>38</volume><issue>S1</issue><spage>E1625</spage><epage>E1638</epage><pages>E1625-E1638</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of recurrence, and with few approved targeted agents, novel treatments are needed. We analyzed a molecular profiling database for the distribution of biomarkers predictive of chemotherapies and targeted agents.
Methods
Seven hundred thirty‐five patients with advanced HNSCC (88 with known human papillomavirus [HPV] status), were profiled using multiple platforms (gene sequencing, gene copy number, and protein expression).
Results
Among the entire patient population studied, epidermal growth factor receptor (EGFR) was the protein most often overexpressed (90%), TP53 gene most often mutated (41%), and phosphatidylinositol 3‐kinase (PIK3CA) most often amplified (40%; n = 5). With the exception of TP53 mutation, other biomarker frequencies were not significantly different among HPV‐positive or HPV‐negative patients. PIK3CA mutations and phosphatase and tensin homolog (PTEN) loss are frequent events, independent of HPV status. The immune response‐modulating programmed cell death 1 (PD1) and programmed cell death ligand 1 (PDL1) axis was active across sites, stages, and HPV status.
Conclusion
Molecular profiling utilizing multiple platforms provides a range of therapy options beyond standard of care. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1625–E1638, 2016</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26614708</pmid><doi>10.1002/hed.24290</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over B7-H1 Antigen - genetics biomarkers Biomarkers, Tumor - genetics Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Class I Phosphatidylinositol 3-Kinases - genetics DNA sequencing Female Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - genetics head and neck squamous cell carcinoma Humans Male Middle Aged molecular profiling Mutation Neoplasm Recurrence, Local Original Papillomaviridae Papillomavirus Infections Programmed Cell Death 1 Receptor - genetics protein expression PTEN Phosphohydrolase - genetics Receptor, Epidermal Growth Factor - genetics Tumor Suppressor Protein p53 - genetics Young Adult |
| title | Molecular profiling of head and neck squamous cell carcinoma |
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