An HIV-1 capsid binding protein TRIM11 accelerates viral uncoating

Several members of the TRIM family have been implicated in antiviral defense. Our previous report showed that human TRIM11 potently inhibited HIV-1 transduction by reducing the viral reverse transcripts. These results prompted us to examine the effect of TRIM11 on HIV-1 uncoating, which is closely r...

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Veröffentlicht in:	Retrovirology 2016-10, Vol.13 (1), p.72-72, Article 72
Hauptverfasser:	Yuan, Ting, Yao, Weitong, Tokunaga, Kenzo, Yang, Rongge, Sun, Binlian
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antiviral agents Binding proteins Capsid - metabolism Care and treatment Carrier Proteins - genetics Carrier Proteins - metabolism Gene Knockdown Techniques Health aspects HEK293 Cells HIV infection HIV-1 - genetics HIV-1 - metabolism HIV-1 - physiology Host-Pathogen Interactions Humans Influence Reverse Transcription Tripartite Motif Proteins - deficiency Tripartite Motif Proteins - genetics Tripartite Motif Proteins - metabolism Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Virus Replication Virus Uncoating
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