Epidemiology of American Tegumentary Leishmaniasis and Trypanosoma cruzi Infection in the Northwestern Argentina
Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. in...
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| creator | Krolewiecki, Alejandro J. Nasser, Julio R. Gil, José F. Cimino, Rubén O. Torrejón, Irma Cayo, Melina Alberti D’Amato, Anahí M. Marco, Jorge D. Juarez, Marisa Cajal, Silvana P. Hoyos, Carlos L. Diosque, Patricio |
| description | Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potential associated risk factors, the serologic prevalence of T. cruzi, and the presence of T. cruzi-Leishmania sp. mixed infection in a region of the northwest of Argentina. Methods. Cross-sectional studies were conducted to detect TL prevalence and T. cruzi seroprevalence. A case-control study was conducted to examine leishmaniasis risk factors. Results. Prevalence of TL was 0.17%, seroprevalence of T. cruzi infection was 9.73%, and mixed infection proportion—within the leishmaniasic patients group—was 16.67%. The risk factors associated with TL transmission were sex, age, exposure to bites at work, staying outdoors more than 10 hours/day, bathing in the river, and living with people who had lesions or were infected during the study. Discussion. The endemic pattern of TL seems to involve exposure of patients to vectors in wild as well as peridomestic environment. Cases of T. cruzi infection are apparently due to migration. Therefore, a careful epidemiological surveillance is necessary due to the contraindication of antimonial administration to chagasic patients. |
| doi_str_mv | 10.1155/2016/6456031 |
| format | Article |
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Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potential associated risk factors, the serologic prevalence of T. cruzi, and the presence of T. cruzi-Leishmania sp. mixed infection in a region of the northwest of Argentina. Methods. Cross-sectional studies were conducted to detect TL prevalence and T. cruzi seroprevalence. A case-control study was conducted to examine leishmaniasis risk factors. Results. Prevalence of TL was 0.17%, seroprevalence of T. cruzi infection was 9.73%, and mixed infection proportion—within the leishmaniasic patients group—was 16.67%. The risk factors associated with TL transmission were sex, age, exposure to bites at work, staying outdoors more than 10 hours/day, bathing in the river, and living with people who had lesions or were infected during the study. Discussion. The endemic pattern of TL seems to involve exposure of patients to vectors in wild as well as peridomestic environment. Cases of T. cruzi infection are apparently due to migration. Therefore, a careful epidemiological surveillance is necessary due to the contraindication of antimonial administration to chagasic patients.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2016/6456031</identifier><identifier>PMID: 27777950</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Adult ; Aged ; Argentina - epidemiology ; Case-Control Studies ; Chagas Disease - epidemiology ; Chagas' disease ; Child ; Coinfection - epidemiology ; Coinfection - parasitology ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Epidemiology ; Female ; Geography ; Health aspects ; Humans ; Infection ; Leishmania ; Leishmaniasis ; Leishmaniasis - epidemiology ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Parasites ; Parasitic diseases ; Prevalence ; Protozoa ; Rainforest ; Risk Factors ; Scandals ; Seroepidemiologic Studies ; Tropical Climate ; Trypanosoma cruzi ; Trypanosomiasis - epidemiology ; Young Adult</subject><ispartof>BioMed research international, 2016-01, Vol.2016 (2016), p.1-8</ispartof><rights>Copyright © 2016 Carlos L. Hoyos et al.</rights><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Carlos L. Hoyos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2016 Carlos L. Hoyos et al. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c494t-f7d4ec8fec56474ece1cbf9b9172216ed267024344cf3d7242c1b8b2f7abb80a3</citedby><cites>FETCH-LOGICAL-c494t-f7d4ec8fec56474ece1cbf9b9172216ed267024344cf3d7242c1b8b2f7abb80a3</cites><orcidid>0000-0003-3994-1265 ; 0000-0001-9054-1211</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061991/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5061991/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27777950$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Vasconcelos, Jose</contributor><creatorcontrib>Krolewiecki, Alejandro J.</creatorcontrib><creatorcontrib>Nasser, Julio R.</creatorcontrib><creatorcontrib>Gil, José F.</creatorcontrib><creatorcontrib>Cimino, Rubén O.</creatorcontrib><creatorcontrib>Torrejón, Irma</creatorcontrib><creatorcontrib>Cayo, Melina</creatorcontrib><creatorcontrib>Alberti D’Amato, Anahí M.</creatorcontrib><creatorcontrib>Marco, Jorge D.</creatorcontrib><creatorcontrib>Juarez, Marisa</creatorcontrib><creatorcontrib>Cajal, Silvana P.</creatorcontrib><creatorcontrib>Hoyos, Carlos L.</creatorcontrib><creatorcontrib>Diosque, Patricio</creatorcontrib><title>Epidemiology of American Tegumentary Leishmaniasis and Trypanosoma cruzi Infection in the Northwestern Argentina</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potential associated risk factors, the serologic prevalence of T. cruzi, and the presence of T. cruzi-Leishmania sp. mixed infection in a region of the northwest of Argentina. Methods. Cross-sectional studies were conducted to detect TL prevalence and T. cruzi seroprevalence. A case-control study was conducted to examine leishmaniasis risk factors. Results. Prevalence of TL was 0.17%, seroprevalence of T. cruzi infection was 9.73%, and mixed infection proportion—within the leishmaniasic patients group—was 16.67%. The risk factors associated with TL transmission were sex, age, exposure to bites at work, staying outdoors more than 10 hours/day, bathing in the river, and living with people who had lesions or were infected during the study. Discussion. The endemic pattern of TL seems to involve exposure of patients to vectors in wild as well as peridomestic environment. Cases of T. cruzi infection are apparently due to migration. Therefore, a careful epidemiological surveillance is necessary due to the contraindication of antimonial administration to chagasic patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Argentina - epidemiology</subject><subject>Case-Control Studies</subject><subject>Chagas Disease - epidemiology</subject><subject>Chagas' disease</subject><subject>Child</subject><subject>Coinfection - epidemiology</subject><subject>Coinfection - parasitology</subject><subject>Cross-Sectional Studies</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Geography</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infection</subject><subject>Leishmania</subject><subject>Leishmaniasis</subject><subject>Leishmaniasis - epidemiology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Middle Aged</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Prevalence</subject><subject>Protozoa</subject><subject>Rainforest</subject><subject>Risk Factors</subject><subject>Scandals</subject><subject>Seroepidemiologic Studies</subject><subject>Tropical Climate</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosomiasis - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krolewiecki, Alejandro J.</au><au>Nasser, Julio R.</au><au>Gil, José F.</au><au>Cimino, Rubén O.</au><au>Torrejón, Irma</au><au>Cayo, Melina</au><au>Alberti D’Amato, Anahí M.</au><au>Marco, Jorge D.</au><au>Juarez, Marisa</au><au>Cajal, Silvana P.</au><au>Hoyos, Carlos L.</au><au>Diosque, Patricio</au><au>Vasconcelos, Jose</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology of American Tegumentary Leishmaniasis and Trypanosoma cruzi Infection in the Northwestern Argentina</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>2016</volume><issue>2016</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potential associated risk factors, the serologic prevalence of T. cruzi, and the presence of T. cruzi-Leishmania sp. mixed infection in a region of the northwest of Argentina. Methods. Cross-sectional studies were conducted to detect TL prevalence and T. cruzi seroprevalence. A case-control study was conducted to examine leishmaniasis risk factors. Results. Prevalence of TL was 0.17%, seroprevalence of T. cruzi infection was 9.73%, and mixed infection proportion—within the leishmaniasic patients group—was 16.67%. The risk factors associated with TL transmission were sex, age, exposure to bites at work, staying outdoors more than 10 hours/day, bathing in the river, and living with people who had lesions or were infected during the study. Discussion. The endemic pattern of TL seems to involve exposure of patients to vectors in wild as well as peridomestic environment. Cases of T. cruzi infection are apparently due to migration. Therefore, a careful epidemiological surveillance is necessary due to the contraindication of antimonial administration to chagasic patients.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>27777950</pmid><doi>10.1155/2016/6456031</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3994-1265</orcidid><orcidid>https://orcid.org/0000-0001-9054-1211</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Argentina - epidemiology Case-Control Studies Chagas Disease - epidemiology Chagas' disease Child Coinfection - epidemiology Coinfection - parasitology Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Epidemiology Female Geography Health aspects Humans Infection Leishmania Leishmaniasis Leishmaniasis - epidemiology Male Medical research Medicine, Experimental Middle Aged Parasites Parasitic diseases Prevalence Protozoa Rainforest Risk Factors Scandals Seroepidemiologic Studies Tropical Climate Trypanosoma cruzi Trypanosomiasis - epidemiology Young Adult |
| title | Epidemiology of American Tegumentary Leishmaniasis and Trypanosoma cruzi Infection in the Northwestern Argentina |
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