Inflammation induced by inhaled lipopolysaccharide depends on particle size in healthy volunteers

Aims In drug development, the anti‐inflammatory properties of new molecules in the lung are currently tested using the inhaled lipopolysaccharide (LPS) model. The total and regional lung bioavailability of inhaled particles depends significantly on their size. The objective of the present study was...

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Veröffentlicht in:	British journal of clinical pharmacology 2016-11, Vol.82 (5), p.1371-1381
Hauptverfasser:	Doyen, Virginie, Pilcer, Gabrielle, Dinh, Phong Huy Duc, Corazza, Francis, Bernard, Alfred, Bergmann, Pierre, Lefevre, Nicolas, Amighi, Karim, Michel, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adolescent Adult asthma C-Reactive Protein - metabolism Cell Count endotoxin Female Healthy Volunteers Humans inflammation Inflammation - chemically induced Inflammation - metabolism Lipopolysaccharides - administration & dosage Lipopolysaccharides - pharmacokinetics Lung - metabolism lung deposition Male Methods in Clinical Pharmacology Middle Aged Nebulizers and Vaporizers Neutrophils - drug effects Particle Size Radionuclide Imaging Sputum - cytology Technetium - administration & dosage Technetium - pharmacokinetics Young Adult
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