An Immunocytochemical-Derived Correlate for Evaluating the Bridging of Heteromeric Mu-Delta Opioid Protomers by Bivalent Ligands

Bivalent ligands that contain two pharmacophores linked by a spacer are promising tools to investigate the pharmacology of opioid receptor heteromers. Evidence for occupation of neighboring protomers by two phamacophores of a single bivalent ligand (bridging) has relied mainly on pharmacological dat...

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Veröffentlicht in:	ACS chemical biology 2013-07, Vol.8 (7), p.1412-1416
Hauptverfasser:	Yekkirala, Ajay S, Kalyuzhny, Alexander E, Portoghese, Philip S
Format:	Artikel
Sprache:	eng
Schlagworte:	HEK293 Cells Humans Immobilized Nucleic Acids Immunohistochemistry Ligands Microscopy, Confocal Models, Biological Naltrexone - analogs & derivatives Naltrexone - chemistry Naltrexone - pharmacology Promoter Regions, Genetic - genetics Receptors, Opioid, delta - chemistry Receptors, Opioid, delta - genetics Receptors, Opioid, mu - chemistry Receptors, Opioid, mu - genetics
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