TAK1 regulates caspase 8 activation and necroptotic signaling via multiple cell death checkpoints

Necroptosis has emerged as a new form of programmed cell death implicated in a number of pathological conditions such as ischemic injury, neurodegenerative disease, and viral infection. Recent studies indicate that TGF β -activated kinase 1 (TAK1) is nodal regulator of necroptotic cell death, althou...

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Veröffentlicht in:	Cell death & disease 2016-09, Vol.7 (9), p.e2381-e2381
Hauptverfasser:	Guo, Xiaoyun, Yin, Haifeng, Chen, Yi, Li, Lei, Li, Jing, Liu, Qinghang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/275 631/80/82/23 631/80/82/2344 631/80/86/2371 96/106 96/95 Adaptor proteins Animals Antibodies Apoptosis Biochemistry CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism Caspase 8 - metabolism Caspase-8 Cell Biology Cell Culture Cell Cycle Checkpoints Cell death Cell survival Cysteine Endopeptidases - metabolism Enzyme Activation FADD protein Fas-Associated Death Domain Protein - metabolism FLIP protein Humans Immunology Ischemia Life Sciences MAP Kinase Kinase Kinases - metabolism Mice Necroptosis Necrosis Neurodegenerative diseases NF-kappa B - metabolism NF-κB protein Original original-article Phosphorylation Proteasome Endopeptidase Complex - metabolism Proteasomes Proteolysis Signal Transduction TAK1 protein TNF Receptor-Associated Death Domain Protein - metabolism Tumor necrosis factor receptors Tumor necrosis factor-α Ubiquitin Ubiquitin - metabolism
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