Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in a Parkinson disease mouse model

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival and regeneration-promoting factor for dopaminergic neurons in cell and animal models of Parkinson disease (PD). GDNF is currently tested in clinical trials on PD patients with so far inconclusive results. The receptor tyrosine k...

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Veröffentlicht in:	Cell death & disease 2016-09, Vol.7 (9), p.e2359-e2359
Hauptverfasser:	Drinkut, Anja, Tillack, Karsten, Meka, Durga P, Schulz, Jorg B, Kügler, Sebastian, Kramer, Edgar R
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 42 42/44 631/378/1689/1718 631/80/86 692/700/565 96 96/95 Animal models Animals Antibodies Biochemistry Cell Biology Cell Culture Clinical trials Disease Models, Animal Dopamine receptors Dopaminergic Neurons - drug effects Dopaminergic Neurons - metabolism Dopaminergic Neurons - pathology Gene Expression Glial cell line-derived neurotrophic factor Glial Cell Line-Derived Neurotrophic Factor - metabolism Glial Cell Line-Derived Neurotrophic Factor - pharmacology Glial cells Humans Immunology Injections, Intraventricular Life Sciences Male Mesencephalon Mesencephalon - drug effects Mesencephalon - metabolism Mesencephalon - pathology Mice Mice, Knockout Movement disorders MPTP Neostriatum Neostriatum - drug effects Neostriatum - metabolism Neostriatum - pathology Neurodegeneration Neurodegenerative diseases Neuronal-glial interactions Neurons Neuroprotection Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology Neurotrophic factors Original original-article Parkinson Disease - drug therapy Parkinson Disease - genetics Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Protein-tyrosine kinase receptors Proto-Oncogene Proteins c-ret - deficiency Proto-Oncogene Proteins c-ret - genetics Regeneration Ret protein Rodents Signal Transduction Stereotaxic Techniques Substantia Nigra - drug effects Substantia Nigra - metabolism Substantia Nigra - pathology
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