Role of NOS2 in pulmonary injury and repair in response to bleomycin

Nitric oxide (NO) is derived from multiple isoforms of the Nitric Oxide Synthases (NOSs) within the lung for a variety of functions; however, NOS2-derived nitrogen oxides seem to play an important role in inflammatory regulation. In this study, we investigate the role of NOS2 in pulmonary inflammati...

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Veröffentlicht in:	Free radical biology & medicine 2016-02, Vol.91, p.293-301
Hauptverfasser:	Guo, Changjiang, Atochina-Vasserman, Elena, Abramova, Helen, George, Blessy, Manoj, Veleeparambil, Scott, Pamela, Gow, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bleomycin Lipopolysaccharides - pharmacology Lung - enzymology Lung - immunology Lung - pathology Lung Injury - chemically induced Lung Injury - enzymology Lung Injury - immunology Macrophage Activation Mice, Inbred C57BL Nitric Oxide Synthase Type II - physiology NOS2 inhibitor Pulmonary inflammation Regeneration S-nitrosylation Surfactant protein-D Transcriptome
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