Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle
The oral pharmacokinetics of diclofenac (DF) were evaluated in cattle by analyzing plasma concentration-time data after its intravenous and oral administration in order to propose the oral administration of DF as effective route to avoid long withdraw period. DF was intravenously and orally administ...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2016, Vol.78(9), pp.1481-1485 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | SAWAGUCHI, Akiyo SASAKI, Kazuaki MIYANAGA, Keisuke NAKAYAMA, Mitsuhiro NAGASUE, Masato SHIMODA, Minoru |
| description | The oral pharmacokinetics of diclofenac (DF) were evaluated in cattle by analyzing plasma concentration-time data after its intravenous and oral administration in order to propose the oral administration of DF as effective route to avoid long withdraw period. DF was intravenously and orally administered at 1 mg/kg to cattle using a crossover design with a 4-week washout period. Plasma concentrations of DF were determined by a HPLC analysis. The mean absorption time (MAT) and absorption half-life (t1/2ka) were 1.61 ± 0.61 and 1.51 ± 0.38 hr, respectively, and bioavailability was nearly 100%. The oral pharmacokinetics of acetaminophen (AAP) were also evaluated in cattle. Plasma concentrations of AAP were determined by a HPLC analysis. MAT and t1/2ka were 2.85 ± 0.93 and 1.53 ± 0.28 hr, respectively, and bioavailability was approximately 70%. In conclusion, the results of the present study indicate that DF and AAP are rapidly absorbed from the forestomach of cattle. Therefore, the appropriate efficacies of these drugs may be achieved via their oral administration, even in cattle. |
| doi_str_mv | 10.1292/jvms.16-0202 |
| format | Article |
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DF was intravenously and orally administered at 1 mg/kg to cattle using a crossover design with a 4-week washout period. Plasma concentrations of DF were determined by a HPLC analysis. The mean absorption time (MAT) and absorption half-life (t1/2ka) were 1.61 ± 0.61 and 1.51 ± 0.38 hr, respectively, and bioavailability was nearly 100%. The oral pharmacokinetics of acetaminophen (AAP) were also evaluated in cattle. Plasma concentrations of AAP were determined by a HPLC analysis. MAT and t1/2ka were 2.85 ± 0.93 and 1.53 ± 0.28 hr, respectively, and bioavailability was approximately 70%. In conclusion, the results of the present study indicate that DF and AAP are rapidly absorbed from the forestomach of cattle. Therefore, the appropriate efficacies of these drugs may be achieved via their oral administration, even in cattle.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.16-0202</identifier><identifier>PMID: 27320817</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Absorption ; Acetaminophen ; Acetaminophen - administration & dosage ; Acetaminophen - blood ; Acetaminophen - pharmacokinetics ; Administration, Oral ; Analgesics ; Analgesics, Non-Narcotic - administration & dosage ; Analgesics, Non-Narcotic - blood ; Analgesics, Non-Narcotic - pharmacokinetics ; Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - blood ; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics ; Bioavailability ; Cattle ; Cattle - blood ; Cattle - metabolism ; Crossovers ; Diclofenac ; Diclofenac - administration & dosage ; Diclofenac - blood ; Diclofenac - pharmacokinetics ; High-performance liquid chromatography ; Injections, Intravenous - veterinary ; Intravenous administration ; Liquid chromatography ; Male ; Nonsteroidal anti-inflammatory drugs ; oral absorption ; Oral administration ; Pharmacokinetics ; Pharmacology</subject><ispartof>Journal of Veterinary Medical Science, 2016, Vol.78(9), pp.1481-1485</ispartof><rights>2016 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency Sep 2016</rights><rights>2016 The Japanese Society of Veterinary Science 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c561t-41712cdaa9809aa28a76fcb0795eeb75a07859d56e5135da44f58b0780b01eb63</citedby><cites>FETCH-LOGICAL-c561t-41712cdaa9809aa28a76fcb0795eeb75a07859d56e5135da44f58b0780b01eb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059376/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059376/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1883,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27320817$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAWAGUCHI, Akiyo</creatorcontrib><creatorcontrib>SASAKI, Kazuaki</creatorcontrib><creatorcontrib>MIYANAGA, Keisuke</creatorcontrib><creatorcontrib>NAKAYAMA, Mitsuhiro</creatorcontrib><creatorcontrib>NAGASUE, Masato</creatorcontrib><creatorcontrib>SHIMODA, Minoru</creatorcontrib><title>Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>The oral pharmacokinetics of diclofenac (DF) were evaluated in cattle by analyzing plasma concentration-time data after its intravenous and oral administration in order to propose the oral administration of DF as effective route to avoid long withdraw period. DF was intravenously and orally administered at 1 mg/kg to cattle using a crossover design with a 4-week washout period. Plasma concentrations of DF were determined by a HPLC analysis. The mean absorption time (MAT) and absorption half-life (t1/2ka) were 1.61 ± 0.61 and 1.51 ± 0.38 hr, respectively, and bioavailability was nearly 100%. The oral pharmacokinetics of acetaminophen (AAP) were also evaluated in cattle. Plasma concentrations of AAP were determined by a HPLC analysis. MAT and t1/2ka were 2.85 ± 0.93 and 1.53 ± 0.28 hr, respectively, and bioavailability was approximately 70%. In conclusion, the results of the present study indicate that DF and AAP are rapidly absorbed from the forestomach of cattle. Therefore, the appropriate efficacies of these drugs may be achieved via their oral administration, even in cattle.</description><subject>Absorption</subject><subject>Acetaminophen</subject><subject>Acetaminophen - administration & dosage</subject><subject>Acetaminophen - blood</subject><subject>Acetaminophen - pharmacokinetics</subject><subject>Administration, Oral</subject><subject>Analgesics</subject><subject>Analgesics, Non-Narcotic - administration & dosage</subject><subject>Analgesics, Non-Narcotic - blood</subject><subject>Analgesics, Non-Narcotic - pharmacokinetics</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - blood</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</subject><subject>Bioavailability</subject><subject>Cattle</subject><subject>Cattle - blood</subject><subject>Cattle - metabolism</subject><subject>Crossovers</subject><subject>Diclofenac</subject><subject>Diclofenac - administration & dosage</subject><subject>Diclofenac - blood</subject><subject>Diclofenac - pharmacokinetics</subject><subject>High-performance liquid chromatography</subject><subject>Injections, Intravenous - veterinary</subject><subject>Intravenous administration</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>oral absorption</subject><subject>Oral administration</subject><subject>Pharmacokinetics</subject><subject>Pharmacology</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcGL1DAUh4O4uOPqzbMUvHiwa5I2SXMRdFF3YUEQvXgJr-nrToY2qUlmYf97U2cc1EsC-b78eI8fIS8YvWRc87e7-zldMllTTvkjsmFNq2rVNvox2VBd3hUX9Jw8TWlHKWet1E_IOVcNpx1TG_LjKyxuqKBPIS7ZBV-FsRqcncKIHmwFvkCLGWbnw7JFX8GYMVZ5iy5WIcJUwVCYSznC7_85VBZynvAZORthSvj8eF-Q758-fru6rm-_fL65en9bWyFZrlumGLcDgO6oBuAdKDnaniotEHslgKpO6EFIFKwRA7TtKLqCO9pThr1sLsi7Q-6y72ccLPoyymSW6GaIDyaAM_8S77bmLtwbQYVu1Brw-hgQw889pmxmlyxOE3gM-2RYx6WijAlV1Ff_qbuwj76sZzhvtCwqY8V6c7BsDClFHE_DMGrW0sxammHSrKUV_eXfC5zkPy0V4cNB2KUMd3gSIObSFB7SVGf0ehxTT9BuIRr0zS_R46xD</recordid><startdate>20160901</startdate><enddate>20160901</enddate><creator>SAWAGUCHI, Akiyo</creator><creator>SASAKI, Kazuaki</creator><creator>MIYANAGA, Keisuke</creator><creator>NAKAYAMA, Mitsuhiro</creator><creator>NAGASUE, Masato</creator><creator>SHIMODA, Minoru</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><general>The Japanese Society of Veterinary Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160901</creationdate><title>Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle</title><author>SAWAGUCHI, Akiyo ; SASAKI, Kazuaki ; MIYANAGA, Keisuke ; NAKAYAMA, Mitsuhiro ; NAGASUE, Masato ; SHIMODA, Minoru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c561t-41712cdaa9809aa28a76fcb0795eeb75a07859d56e5135da44f58b0780b01eb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Absorption</topic><topic>Acetaminophen</topic><topic>Acetaminophen - administration & dosage</topic><topic>Acetaminophen - blood</topic><topic>Acetaminophen - pharmacokinetics</topic><topic>Administration, Oral</topic><topic>Analgesics</topic><topic>Analgesics, Non-Narcotic - administration & dosage</topic><topic>Analgesics, Non-Narcotic - blood</topic><topic>Analgesics, Non-Narcotic - pharmacokinetics</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - blood</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics</topic><topic>Bioavailability</topic><topic>Cattle</topic><topic>Cattle - blood</topic><topic>Cattle - metabolism</topic><topic>Crossovers</topic><topic>Diclofenac</topic><topic>Diclofenac - administration & dosage</topic><topic>Diclofenac - blood</topic><topic>Diclofenac - pharmacokinetics</topic><topic>High-performance liquid chromatography</topic><topic>Injections, Intravenous - veterinary</topic><topic>Intravenous administration</topic><topic>Liquid chromatography</topic><topic>Male</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>oral absorption</topic><topic>Oral administration</topic><topic>Pharmacokinetics</topic><topic>Pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAWAGUCHI, Akiyo</creatorcontrib><creatorcontrib>SASAKI, Kazuaki</creatorcontrib><creatorcontrib>MIYANAGA, Keisuke</creatorcontrib><creatorcontrib>NAKAYAMA, Mitsuhiro</creatorcontrib><creatorcontrib>NAGASUE, Masato</creatorcontrib><creatorcontrib>SHIMODA, Minoru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAWAGUCHI, Akiyo</au><au>SASAKI, Kazuaki</au><au>MIYANAGA, Keisuke</au><au>NAKAYAMA, Mitsuhiro</au><au>NAGASUE, Masato</au><au>SHIMODA, Minoru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2016-09-01</date><risdate>2016</risdate><volume>78</volume><issue>9</issue><spage>1481</spage><epage>1485</epage><pages>1481-1485</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>The oral pharmacokinetics of diclofenac (DF) were evaluated in cattle by analyzing plasma concentration-time data after its intravenous and oral administration in order to propose the oral administration of DF as effective route to avoid long withdraw period. DF was intravenously and orally administered at 1 mg/kg to cattle using a crossover design with a 4-week washout period. Plasma concentrations of DF were determined by a HPLC analysis. The mean absorption time (MAT) and absorption half-life (t1/2ka) were 1.61 ± 0.61 and 1.51 ± 0.38 hr, respectively, and bioavailability was nearly 100%. The oral pharmacokinetics of acetaminophen (AAP) were also evaluated in cattle. Plasma concentrations of AAP were determined by a HPLC analysis. MAT and t1/2ka were 2.85 ± 0.93 and 1.53 ± 0.28 hr, respectively, and bioavailability was approximately 70%. In conclusion, the results of the present study indicate that DF and AAP are rapidly absorbed from the forestomach of cattle. Therefore, the appropriate efficacies of these drugs may be achieved via their oral administration, even in cattle.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>27320817</pmid><doi>10.1292/jvms.16-0202</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absorption Acetaminophen Acetaminophen - administration & dosage Acetaminophen - blood Acetaminophen - pharmacokinetics Administration, Oral Analgesics Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - blood Analgesics, Non-Narcotic - pharmacokinetics Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Anti-Inflammatory Agents, Non-Steroidal - blood Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics Bioavailability Cattle Cattle - blood Cattle - metabolism Crossovers Diclofenac Diclofenac - administration & dosage Diclofenac - blood Diclofenac - pharmacokinetics High-performance liquid chromatography Injections, Intravenous - veterinary Intravenous administration Liquid chromatography Male Nonsteroidal anti-inflammatory drugs oral absorption Oral administration Pharmacokinetics Pharmacology |
| title | Rapid absorption of diclofenac and acetaminophen after their oral administration to cattle |
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