Gaze shift duration, independent of amplitude, influences the number of spikes in the burst for medium-lead burst neurons in pontine reticular formation
Changes in the direction of the line of sight (gaze) allow successive sampling of the visual environment. Saccadic eye movements accomplish this goal when the head does not move. Medium-lead burst neurons (MLBs) in the paramedian pontine reticular formation (PPRF) discharge a high frequency burst of...
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| Veröffentlicht in: | Experimental brain research 2011-10, Vol.214 (2), p.225-239 |
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| description | Changes in the direction of the line of sight (gaze) allow successive sampling of the visual environment. Saccadic eye movements accomplish this goal when the head does not move. Medium-lead burst neurons (MLBs) in the paramedian pontine reticular formation (PPRF) discharge a high frequency burst of action potentials starting ~12 ms before the saccade begins. A subgroup of MLBs rostral of abducens nucleus monosynaptically excites oculomotor neurons. The number of spikes in the presaccadic burst is correlated with the amplitude of the horizontal component of the saccade, and the peak discharge rate is correlated with peak eye velocity. During head-unrestrained gaze shifts, a linear relationship between the number of action potentials in MLB bursts and gaze (but not eye) amplitude has been reported. The anatomical connection of MLBs to motor neurons and the similarity between the phasic motor neuron burst and MLB discharge have raised questions about the usefulness of counting spikes in MLBs to determine their role in eye-head coordination. We investigated this issue using a behavioral technique that permits a dissociation of eye movement amplitude and duration during constant vector gaze shifts. Surprisingly, during gaze shifts of constant amplitude and direction, we observe a nearly linear, positive correlation between saccade duration and spike number associated with a negative correlation between spike number and saccade amplitude. These data constrain models of the oculomotor controller and may further define the time-dependence of hypothesized neural integration in this system. |
| doi_str_mv | 10.1007/s00221-011-2823-8 |
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G.</creatorcontrib><creatorcontrib>Freedman, Edward G.</creatorcontrib><title>Gaze shift duration, independent of amplitude, influences the number of spikes in the burst for medium-lead burst neurons in pontine reticular formation</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><addtitle>Exp Brain Res</addtitle><description>Changes in the direction of the line of sight (gaze) allow successive sampling of the visual environment. Saccadic eye movements accomplish this goal when the head does not move. Medium-lead burst neurons (MLBs) in the paramedian pontine reticular formation (PPRF) discharge a high frequency burst of action potentials starting ~12 ms before the saccade begins. A subgroup of MLBs rostral of abducens nucleus monosynaptically excites oculomotor neurons. The number of spikes in the presaccadic burst is correlated with the amplitude of the horizontal component of the saccade, and the peak discharge rate is correlated with peak eye velocity. During head-unrestrained gaze shifts, a linear relationship between the number of action potentials in MLB bursts and gaze (but not eye) amplitude has been reported. The anatomical connection of MLBs to motor neurons and the similarity between the phasic motor neuron burst and MLB discharge have raised questions about the usefulness of counting spikes in MLBs to determine their role in eye-head coordination. We investigated this issue using a behavioral technique that permits a dissociation of eye movement amplitude and duration during constant vector gaze shifts. Surprisingly, during gaze shifts of constant amplitude and direction, we observe a nearly linear, positive correlation between saccade duration and spike number associated with a negative correlation between spike number and saccade amplitude. These data constrain models of the oculomotor controller and may further define the time-dependence of hypothesized neural integration in this system.</description><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Eye movements</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gaze</subject><subject>Head Movements - physiology</subject><subject>Hypotheses</subject><subject>Macaca mulatta</subject><subject>Motor control and motor pathways. 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Vestibular system and equilibration</topic><topic>Neural transmission</topic><topic>Neurology</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Neurosciences</topic><topic>Physiological aspects</topic><topic>Pons</topic><topic>Pons - cytology</topic><topic>Pons - physiology</topic><topic>Psychomotor Performance - physiology</topic><topic>Regulation</topic><topic>Research Article</topic><topic>Reticular Formation - physiology</topic><topic>Saccades (Eye movements)</topic><topic>Saccades - physiology</topic><topic>Time Factors</topic><topic>Velocity</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walton, Mark M. 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G.</au><au>Freedman, Edward G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gaze shift duration, independent of amplitude, influences the number of spikes in the burst for medium-lead burst neurons in pontine reticular formation</atitle><jtitle>Experimental brain research</jtitle><stitle>Exp Brain Res</stitle><addtitle>Exp Brain Res</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>214</volume><issue>2</issue><spage>225</spage><epage>239</epage><pages>225-239</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>Changes in the direction of the line of sight (gaze) allow successive sampling of the visual environment. Saccadic eye movements accomplish this goal when the head does not move. Medium-lead burst neurons (MLBs) in the paramedian pontine reticular formation (PPRF) discharge a high frequency burst of action potentials starting ~12 ms before the saccade begins. A subgroup of MLBs rostral of abducens nucleus monosynaptically excites oculomotor neurons. The number of spikes in the presaccadic burst is correlated with the amplitude of the horizontal component of the saccade, and the peak discharge rate is correlated with peak eye velocity. During head-unrestrained gaze shifts, a linear relationship between the number of action potentials in MLB bursts and gaze (but not eye) amplitude has been reported. The anatomical connection of MLBs to motor neurons and the similarity between the phasic motor neuron burst and MLB discharge have raised questions about the usefulness of counting spikes in MLBs to determine their role in eye-head coordination. We investigated this issue using a behavioral technique that permits a dissociation of eye movement amplitude and duration during constant vector gaze shifts. Surprisingly, during gaze shifts of constant amplitude and direction, we observe a nearly linear, positive correlation between saccade duration and spike number associated with a negative correlation between spike number and saccade amplitude. These data constrain models of the oculomotor controller and may further define the time-dependence of hypothesized neural integration in this system.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21842410</pmid><doi>10.1007/s00221-011-2823-8</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Action Potentials - physiology Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Eye and associated structures. Visual pathways and centers. Vision Eye movements Female Fundamental and applied biological sciences. Psychology Gaze Head Movements - physiology Hypotheses Macaca mulatta Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Neural transmission Neurology Neurons Neurons - physiology Neurosciences Physiological aspects Pons Pons - cytology Pons - physiology Psychomotor Performance - physiology Regulation Research Article Reticular Formation - physiology Saccades (Eye movements) Saccades - physiology Time Factors Velocity Vertebrates: nervous system and sense organs |
| title | Gaze shift duration, independent of amplitude, influences the number of spikes in the burst for medium-lead burst neurons in pontine reticular formation |
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