Initial central venous pressure could be a prognostic marker for hemodynamic improvement of polymyxin B direct hemoperfusion: a retrospective cohort study
Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estimate the therapeutic effect before performing the therapy. However, it is still unclear when...
Gespeichert in:
| Veröffentlicht in: | Journal of intensive care 2016-10, Vol.4 (1), p.64-64, Article 64 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 64 |
|---|---|
| container_issue | 1 |
| container_start_page | 64 |
| container_title | Journal of intensive care |
| container_volume | 4 |
| creator | Yamada, Hiroyuki Tsukamoto, Tatsuo Narumiya, Hiromichi Oda, Kazumasa Higaki, Satoshi Iizuka, Ryoji Yanagita, Motoko Deguchi, Masako |
| description | Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estimate the therapeutic effect before performing the therapy. However, it is still unclear when this therapy should be started and what type of sepsis it should be employed for. In this study, we retrospectively examined the clinical effect of patients treated with PMX-DHP by using central venous pressure (CVP).
Seventy patients who received PMX-DHP for septic shock during the study period were recruited and divided into a low CVP group (
= 33, CVP |
| doi_str_mv | 10.1186/s40560-016-0186-8 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5057477</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A470589868</galeid><sourcerecordid>A470589868</sourcerecordid><originalsourceid>FETCH-LOGICAL-c569t-3409e9a16fd71ca705382193efce5560c1cff3580befeba63b928a5b256718903</originalsourceid><addsrcrecordid>eNptUk1v1DAQjRCIVqU_gAuyhIS4pNjJ2nE4IJWKj0qVuMDZcpzxrktiB9tZdf8Kv5YJu5QuIlZka_zmjefNK4rnjF4wJsWbtKJc0JIygb8UpXxUnFaUVyVdtdXjB-eT4jylW0opo7wWsn1anFTN8kl6Wvy89i47PRADPkfct-DDnMgUIaU5AjFhHnrSAdEYC2sfUnaGjDp-h0hsiGQDY-h3Xo8YdiNitjAiFwmWTGHYjbs758l70rsIJv9GTxDtnFzwb5E0Qo4hTXjntku1TYiZpDz3u2fFE6uHBOeH_az49vHD16vP5c2XT9dXlzel4aLNZb2iLbSaCds3zOgGm5QVa2uwBjgqZJixtuaSdmCh06Lu2kpq3lVcNEy2tD4r3u15p7kboT8IoabosMudCtqp4xvvNmodtopT3qyaBgleHwhi-DFDymp0ycAwaA-opWKy5hyfSZdaL_-B3oY5emxvQYm6FRWVf1FrPYBy3gasaxZSdbnCBmUrxYK6-A8KVw84i-DBOowfJbx6kLABPeRNCsOccRTpGMj2QIOjSRHsvRiMqsV8am8-heZTi_nUkvPioYr3GX-sVv8Cy_LXLg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1836396208</pqid></control><display><type>article</type><title>Initial central venous pressure could be a prognostic marker for hemodynamic improvement of polymyxin B direct hemoperfusion: a retrospective cohort study</title><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><creator>Yamada, Hiroyuki ; Tsukamoto, Tatsuo ; Narumiya, Hiromichi ; Oda, Kazumasa ; Higaki, Satoshi ; Iizuka, Ryoji ; Yanagita, Motoko ; Deguchi, Masako</creator><creatorcontrib>Yamada, Hiroyuki ; Tsukamoto, Tatsuo ; Narumiya, Hiromichi ; Oda, Kazumasa ; Higaki, Satoshi ; Iizuka, Ryoji ; Yanagita, Motoko ; Deguchi, Masako</creatorcontrib><description>Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estimate the therapeutic effect before performing the therapy. However, it is still unclear when this therapy should be started and what type of sepsis it should be employed for. In this study, we retrospectively examined the clinical effect of patients treated with PMX-DHP by using central venous pressure (CVP).
Seventy patients who received PMX-DHP for septic shock during the study period were recruited and divided into a low CVP group (
= 33, CVP < 12 mmHg) and a high CVP group (
= 37, CVP≧12 mmHg). The primary endpoint was vasopressor dependency index at 24 hours after starting PMX-DHP, and the secondary endpoint was the 28-day survival rate. Additionally, we performed a multivariate linear regression analysis on the difference in the vasopressor dependency index.
The vasopressor dependency index significantly improved at 24 h in the low CVP group (0.33 to 0.16 mmHg
;
< 0.01) but not in the high CVP group (0.43 to 0.34 mmHg
;
= 0.41), and there was a significant difference between the two groups in the index at 24 h (
= 0.02). The 28-day survival rate was higher in the low CVP group (79 vs. 43 %;
< 0.01). Multivariate linear regression analysis showed that CVP (
= 0.04) was independently associated with the difference in the vasopressor dependency index.
Our study indicates that the clinical effect of PMX-DHP for septic shock patients with higher CVP (≧12 mmHg) might be limited and that the initial CVP when performing PMX-DHP could function as an independent prognostic marker for the hemodynamic improvement.</description><identifier>ISSN: 2052-0492</identifier><identifier>EISSN: 2052-0492</identifier><identifier>DOI: 10.1186/s40560-016-0186-8</identifier><identifier>PMID: 27777780</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Care and treatment ; Health aspects ; Polymyxin ; Septic shock</subject><ispartof>Journal of intensive care, 2016-10, Vol.4 (1), p.64-64, Article 64</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c569t-3409e9a16fd71ca705382193efce5560c1cff3580befeba63b928a5b256718903</citedby><cites>FETCH-LOGICAL-c569t-3409e9a16fd71ca705382193efce5560c1cff3580befeba63b928a5b256718903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057477/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5057477/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27777780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamada, Hiroyuki</creatorcontrib><creatorcontrib>Tsukamoto, Tatsuo</creatorcontrib><creatorcontrib>Narumiya, Hiromichi</creatorcontrib><creatorcontrib>Oda, Kazumasa</creatorcontrib><creatorcontrib>Higaki, Satoshi</creatorcontrib><creatorcontrib>Iizuka, Ryoji</creatorcontrib><creatorcontrib>Yanagita, Motoko</creatorcontrib><creatorcontrib>Deguchi, Masako</creatorcontrib><title>Initial central venous pressure could be a prognostic marker for hemodynamic improvement of polymyxin B direct hemoperfusion: a retrospective cohort study</title><title>Journal of intensive care</title><addtitle>J Intensive Care</addtitle><description>Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estimate the therapeutic effect before performing the therapy. However, it is still unclear when this therapy should be started and what type of sepsis it should be employed for. In this study, we retrospectively examined the clinical effect of patients treated with PMX-DHP by using central venous pressure (CVP).
Seventy patients who received PMX-DHP for septic shock during the study period were recruited and divided into a low CVP group (
= 33, CVP < 12 mmHg) and a high CVP group (
= 37, CVP≧12 mmHg). The primary endpoint was vasopressor dependency index at 24 hours after starting PMX-DHP, and the secondary endpoint was the 28-day survival rate. Additionally, we performed a multivariate linear regression analysis on the difference in the vasopressor dependency index.
The vasopressor dependency index significantly improved at 24 h in the low CVP group (0.33 to 0.16 mmHg
;
< 0.01) but not in the high CVP group (0.43 to 0.34 mmHg
;
= 0.41), and there was a significant difference between the two groups in the index at 24 h (
= 0.02). The 28-day survival rate was higher in the low CVP group (79 vs. 43 %;
< 0.01). Multivariate linear regression analysis showed that CVP (
= 0.04) was independently associated with the difference in the vasopressor dependency index.
Our study indicates that the clinical effect of PMX-DHP for septic shock patients with higher CVP (≧12 mmHg) might be limited and that the initial CVP when performing PMX-DHP could function as an independent prognostic marker for the hemodynamic improvement.</description><subject>Care and treatment</subject><subject>Health aspects</subject><subject>Polymyxin</subject><subject>Septic shock</subject><issn>2052-0492</issn><issn>2052-0492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUk1v1DAQjRCIVqU_gAuyhIS4pNjJ2nE4IJWKj0qVuMDZcpzxrktiB9tZdf8Kv5YJu5QuIlZka_zmjefNK4rnjF4wJsWbtKJc0JIygb8UpXxUnFaUVyVdtdXjB-eT4jylW0opo7wWsn1anFTN8kl6Wvy89i47PRADPkfct-DDnMgUIaU5AjFhHnrSAdEYC2sfUnaGjDp-h0hsiGQDY-h3Xo8YdiNitjAiFwmWTGHYjbs758l70rsIJv9GTxDtnFzwb5E0Qo4hTXjntku1TYiZpDz3u2fFE6uHBOeH_az49vHD16vP5c2XT9dXlzel4aLNZb2iLbSaCds3zOgGm5QVa2uwBjgqZJixtuaSdmCh06Lu2kpq3lVcNEy2tD4r3u15p7kboT8IoabosMudCtqp4xvvNmodtopT3qyaBgleHwhi-DFDymp0ycAwaA-opWKy5hyfSZdaL_-B3oY5emxvQYm6FRWVf1FrPYBy3gasaxZSdbnCBmUrxYK6-A8KVw84i-DBOowfJbx6kLABPeRNCsOccRTpGMj2QIOjSRHsvRiMqsV8am8-heZTi_nUkvPioYr3GX-sVv8Cy_LXLg</recordid><startdate>20161010</startdate><enddate>20161010</enddate><creator>Yamada, Hiroyuki</creator><creator>Tsukamoto, Tatsuo</creator><creator>Narumiya, Hiromichi</creator><creator>Oda, Kazumasa</creator><creator>Higaki, Satoshi</creator><creator>Iizuka, Ryoji</creator><creator>Yanagita, Motoko</creator><creator>Deguchi, Masako</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161010</creationdate><title>Initial central venous pressure could be a prognostic marker for hemodynamic improvement of polymyxin B direct hemoperfusion: a retrospective cohort study</title><author>Yamada, Hiroyuki ; Tsukamoto, Tatsuo ; Narumiya, Hiromichi ; Oda, Kazumasa ; Higaki, Satoshi ; Iizuka, Ryoji ; Yanagita, Motoko ; Deguchi, Masako</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c569t-3409e9a16fd71ca705382193efce5560c1cff3580befeba63b928a5b256718903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Care and treatment</topic><topic>Health aspects</topic><topic>Polymyxin</topic><topic>Septic shock</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamada, Hiroyuki</creatorcontrib><creatorcontrib>Tsukamoto, Tatsuo</creatorcontrib><creatorcontrib>Narumiya, Hiromichi</creatorcontrib><creatorcontrib>Oda, Kazumasa</creatorcontrib><creatorcontrib>Higaki, Satoshi</creatorcontrib><creatorcontrib>Iizuka, Ryoji</creatorcontrib><creatorcontrib>Yanagita, Motoko</creatorcontrib><creatorcontrib>Deguchi, Masako</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of intensive care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamada, Hiroyuki</au><au>Tsukamoto, Tatsuo</au><au>Narumiya, Hiromichi</au><au>Oda, Kazumasa</au><au>Higaki, Satoshi</au><au>Iizuka, Ryoji</au><au>Yanagita, Motoko</au><au>Deguchi, Masako</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Initial central venous pressure could be a prognostic marker for hemodynamic improvement of polymyxin B direct hemoperfusion: a retrospective cohort study</atitle><jtitle>Journal of intensive care</jtitle><addtitle>J Intensive Care</addtitle><date>2016-10-10</date><risdate>2016</risdate><volume>4</volume><issue>1</issue><spage>64</spage><epage>64</epage><pages>64-64</pages><artnum>64</artnum><issn>2052-0492</issn><eissn>2052-0492</eissn><abstract>Direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP) could improve the hemodynamic status of septic shock patients. As PMX-DHP is an invasive and costly procedure, it is desirable to estimate the therapeutic effect before performing the therapy. However, it is still unclear when this therapy should be started and what type of sepsis it should be employed for. In this study, we retrospectively examined the clinical effect of patients treated with PMX-DHP by using central venous pressure (CVP).
Seventy patients who received PMX-DHP for septic shock during the study period were recruited and divided into a low CVP group (
= 33, CVP < 12 mmHg) and a high CVP group (
= 37, CVP≧12 mmHg). The primary endpoint was vasopressor dependency index at 24 hours after starting PMX-DHP, and the secondary endpoint was the 28-day survival rate. Additionally, we performed a multivariate linear regression analysis on the difference in the vasopressor dependency index.
The vasopressor dependency index significantly improved at 24 h in the low CVP group (0.33 to 0.16 mmHg
;
< 0.01) but not in the high CVP group (0.43 to 0.34 mmHg
;
= 0.41), and there was a significant difference between the two groups in the index at 24 h (
= 0.02). The 28-day survival rate was higher in the low CVP group (79 vs. 43 %;
< 0.01). Multivariate linear regression analysis showed that CVP (
= 0.04) was independently associated with the difference in the vasopressor dependency index.
Our study indicates that the clinical effect of PMX-DHP for septic shock patients with higher CVP (≧12 mmHg) might be limited and that the initial CVP when performing PMX-DHP could function as an independent prognostic marker for the hemodynamic improvement.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27777780</pmid><doi>10.1186/s40560-016-0186-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2052-0492 |
| ispartof | Journal of intensive care, 2016-10, Vol.4 (1), p.64-64, Article 64 |
| issn | 2052-0492 2052-0492 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5057477 |
| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Care and treatment Health aspects Polymyxin Septic shock |
| title | Initial central venous pressure could be a prognostic marker for hemodynamic improvement of polymyxin B direct hemoperfusion: a retrospective cohort study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T10%3A20%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Initial%20central%20venous%20pressure%20could%20be%20a%20prognostic%20marker%20for%20hemodynamic%20improvement%20of%20polymyxin%20B%20direct%20hemoperfusion:%20a%20retrospective%20cohort%20study&rft.jtitle=Journal%20of%20intensive%20care&rft.au=Yamada,%20Hiroyuki&rft.date=2016-10-10&rft.volume=4&rft.issue=1&rft.spage=64&rft.epage=64&rft.pages=64-64&rft.artnum=64&rft.issn=2052-0492&rft.eissn=2052-0492&rft_id=info:doi/10.1186/s40560-016-0186-8&rft_dat=%3Cgale_pubme%3EA470589868%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1836396208&rft_id=info:pmid/27777780&rft_galeid=A470589868&rfr_iscdi=true |