Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells

The membrane fusion of secretory granules with plasma membranes is crucial for the exocytosis of hormones and enzymes. Secretion disorders can cause various diseases such as diabetes or pancreatitis. Synaptosomal-associated protein 23 (SNAP23), a soluble N-ethyl-maleimide sensitive fusion protein at...

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Veröffentlicht in:	The Journal of cell biology 2016-10, Vol.215 (1), p.121-138
Hauptverfasser:	Kunii, Masataka, Ohara-Imaizumi, Mica, Takahashi, Noriko, Kobayashi, Masaki, Kawakami, Ryosuke, Kondoh, Yasumitsu, Shimizu, Takeshi, Simizu, Siro, Lin, Bangzhong, Nunomura, Kazuto, Aoyagi, Kyota, Ohno, Mitsuyo, Ohmuraya, Masaki, Sato, Takashi, Yoshimura, Shin-Ichiro, Sato, Ken, Harada, Reiko, Kim, Yoon-Jeong, Osada, Hiroyuki, Nemoto, Tomomi, Kasai, Haruo, Kitamura, Tadahiro, Nagamatsu, Shinya, Harada, Akihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - metabolism Acinar Cells - ultrastructure Amylases - metabolism Animals Cell Fusion Cells Cellular biology Enzymes Exocytosis Glucose Transporter Type 4 - metabolism Insulin - metabolism Insulin Secretion Islets of Langerhans - cytology Membranes Mice, Knockout Microscopy, Fluorescence, Multiphoton Models, Biological Molecular weight Pancreas, Exocrine - cytology Parotid Gland - cytology Protein Transport Proteins Qb-SNARE Proteins - deficiency Qb-SNARE Proteins - metabolism Qc-SNARE Proteins - deficiency Qc-SNARE Proteins - metabolism Secretory Vesicles - metabolism SNARE Proteins - metabolism Synaptosomal-Associated Protein 25 - metabolism
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