Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus
Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant Camponotus floridanus, morphologically distinct worker castes called minors and majors exhibit pronounced differences i...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2016-01, Vol.351 (6268), p.42-42 |
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| creator | Simola, Daniel F. Graham, Riley J. Brady, Cristina M. Enzmann, Brittany L. Desplan, Claude Ray, Anandasankar Zwiebel, Laurence J. Bonasio, Roberto Reinberg, Danny Liebig, Jürgen Berger, Shelley L. |
| description | Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant Camponotus floridanus, morphologically distinct worker castes called minors and majors exhibit pronounced differences in foraging and scouting behaviors. We found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved acetyltransferase CBP. Transcriptome and chromatin analysis in brains of scouting minors fed pharmacological inhibitors of CBP and histone deacetylases (HDACs) revealed hundreds of genes linked to hyperacetylated regions targeted by CBP. Majors rarely forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young major brains induced and sustained foraging in a CBP-dependent manner. Our results suggest that behavioral plasticity in animals may be regulated in an epigenetic manner via histone modification. |
| doi_str_mv | 10.1126/science.aac6633 |
| format | Article |
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In the carpenter ant Camponotus floridanus, morphologically distinct worker castes called minors and majors exhibit pronounced differences in foraging and scouting behaviors. We found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved acetyltransferase CBP. Transcriptome and chromatin analysis in brains of scouting minors fed pharmacological inhibitors of CBP and histone deacetylases (HDACs) revealed hundreds of genes linked to hyperacetylated regions targeted by CBP. Majors rarely forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young major brains induced and sustained foraging in a CBP-dependent manner. Our results suggest that behavioral plasticity in animals may be regulated in an epigenetic manner via histone modification.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.aac6633</identifier><identifier>PMID: 26722000</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Acetylation ; Animal behavior ; Animals ; Ants ; Ants - drug effects ; Ants - genetics ; Ants - physiology ; Behavior, Animal ; Brain ; Camponotus ; Chromatin - metabolism ; Control ; Epigenesis, Genetic ; Forages ; Formicidae ; Genes ; Histone Deacetylase 2 - antagonists & inhibitors ; Histone Deacetylase 2 - genetics ; Histone Deacetylase 2 - physiology ; Histone Deacetylase Inhibitors - pharmacology ; Histones ; Inhibitors ; Insects ; Labor ; Narcotics ; Protein Processing, Post-Translational ; RESEARCH ARTICLE SUMMARY ; Ribonucleic acid ; RNA ; Social Behavior ; Social Class ; Transcriptome</subject><ispartof>Science (American Association for the Advancement of Science), 2016-01, Vol.351 (6268), p.42-42</ispartof><rights>Copyright © 2016 American Association for the Advancement of Science</rights><rights>Copyright © 2016, American Association for the Advancement of Science.</rights><rights>Copyright © 2016, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-3c89c4e0653ce35321df9579fb10786e8d338ce9a5fbe13ac4dc47c85e4fd9873</citedby><cites>FETCH-LOGICAL-c468t-3c89c4e0653ce35321df9579fb10786e8d338ce9a5fbe13ac4dc47c85e4fd9873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24741390$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24741390$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,315,781,785,804,886,2885,2886,27926,27927,58019,58252</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26722000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simola, Daniel F.</creatorcontrib><creatorcontrib>Graham, Riley J.</creatorcontrib><creatorcontrib>Brady, Cristina M.</creatorcontrib><creatorcontrib>Enzmann, Brittany L.</creatorcontrib><creatorcontrib>Desplan, Claude</creatorcontrib><creatorcontrib>Ray, Anandasankar</creatorcontrib><creatorcontrib>Zwiebel, Laurence J.</creatorcontrib><creatorcontrib>Bonasio, Roberto</creatorcontrib><creatorcontrib>Reinberg, Danny</creatorcontrib><creatorcontrib>Liebig, Jürgen</creatorcontrib><creatorcontrib>Berger, Shelley L.</creatorcontrib><title>Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant Camponotus floridanus, morphologically distinct worker castes called minors and majors exhibit pronounced differences in foraging and scouting behaviors. We found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved acetyltransferase CBP. Transcriptome and chromatin analysis in brains of scouting minors fed pharmacological inhibitors of CBP and histone deacetylases (HDACs) revealed hundreds of genes linked to hyperacetylated regions targeted by CBP. Majors rarely forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young major brains induced and sustained foraging in a CBP-dependent manner. Our results suggest that behavioral plasticity in animals may be regulated in an epigenetic manner via histone modification.</description><subject>Acetylation</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Ants</subject><subject>Ants - drug effects</subject><subject>Ants - genetics</subject><subject>Ants - physiology</subject><subject>Behavior, Animal</subject><subject>Brain</subject><subject>Camponotus</subject><subject>Chromatin - metabolism</subject><subject>Control</subject><subject>Epigenesis, Genetic</subject><subject>Forages</subject><subject>Formicidae</subject><subject>Genes</subject><subject>Histone Deacetylase 2 - antagonists & inhibitors</subject><subject>Histone Deacetylase 2 - genetics</subject><subject>Histone Deacetylase 2 - physiology</subject><subject>Histone Deacetylase Inhibitors - pharmacology</subject><subject>Histones</subject><subject>Inhibitors</subject><subject>Insects</subject><subject>Labor</subject><subject>Narcotics</subject><subject>Protein Processing, Post-Translational</subject><subject>RESEARCH ARTICLE SUMMARY</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Social Behavior</subject><subject>Social Class</subject><subject>Transcriptome</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9rFDEUB_AgFrtWz56UAS_1MO3LZPLrUpClaqHgRb2GbObNbpaZZExmCv73Rnat2kvNJYT3yRfy8gh5ReGC0kZcZucxOLyw1gnB2BOyoqB5rRtgT8kKgIlageSn5HnOe4BS0-wZOW2EbJpyXJFv15PfYsDZu-o84bspxW2y4-jDtop95Wyesc4TOt8XscGdvfMxVT5U8w4rG-ZqbccphjgvueqHmHxnw5JfkJPeDhlfHvcz8vXD9Zf1p_r288eb9fvb2rVCzTVzSrsWQXDmkHHW0K7XXOp-Q0EqgapjTDnUlvcbpMy6tnOtdIpj23daSXZGrg6507IZsXMY5mQHMyU_2vTDROvNv5Xgd2Yb7wwHLqniJeD8GJDi9wXzbEafHQ6DDRiXbKhqeFmyhf-glGrQAOJxKjkDUFyyQt8-oPu4pFCadlCi1YoWdXlQLsWcE_b3T6Rgfk2COU6COU5CufHm787c-99fX8DrA9jnOaY_9Va2lGlgPwErF7sp</recordid><startdate>20160101</startdate><enddate>20160101</enddate><creator>Simola, Daniel F.</creator><creator>Graham, Riley J.</creator><creator>Brady, Cristina M.</creator><creator>Enzmann, Brittany L.</creator><creator>Desplan, Claude</creator><creator>Ray, Anandasankar</creator><creator>Zwiebel, Laurence J.</creator><creator>Bonasio, Roberto</creator><creator>Reinberg, Danny</creator><creator>Liebig, Jürgen</creator><creator>Berger, Shelley L.</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160101</creationdate><title>Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus</title><author>Simola, Daniel F. ; Graham, Riley J. ; Brady, Cristina M. ; Enzmann, Brittany L. ; Desplan, Claude ; Ray, Anandasankar ; Zwiebel, Laurence J. ; Bonasio, Roberto ; Reinberg, Danny ; Liebig, Jürgen ; Berger, Shelley L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-3c89c4e0653ce35321df9579fb10786e8d338ce9a5fbe13ac4dc47c85e4fd9873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acetylation</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Ants</topic><topic>Ants - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simola, Daniel F.</au><au>Graham, Riley J.</au><au>Brady, Cristina M.</au><au>Enzmann, Brittany L.</au><au>Desplan, Claude</au><au>Ray, Anandasankar</au><au>Zwiebel, Laurence J.</au><au>Bonasio, Roberto</au><au>Reinberg, Danny</au><au>Liebig, Jürgen</au><au>Berger, Shelley L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2016-01-01</date><risdate>2016</risdate><volume>351</volume><issue>6268</issue><spage>42</spage><epage>42</epage><pages>42-42</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Eusocial insects organize themselves into behavioral castes whose regulation has been proposed to involve epigenetic processes, including histone modification. In the carpenter ant Camponotus floridanus, morphologically distinct worker castes called minors and majors exhibit pronounced differences in foraging and scouting behaviors. We found that these behaviors are regulated by histone acetylation likely catalyzed by the conserved acetyltransferase CBP. Transcriptome and chromatin analysis in brains of scouting minors fed pharmacological inhibitors of CBP and histone deacetylases (HDACs) revealed hundreds of genes linked to hyperacetylated regions targeted by CBP. Majors rarely forage, but injection of a HDAC inhibitor or small interfering RNAs against the HDAC Rpd3 into young major brains induced and sustained foraging in a CBP-dependent manner. Our results suggest that behavioral plasticity in animals may be regulated in an epigenetic manner via histone modification.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>26722000</pmid><doi>10.1126/science.aac6633</doi><tpages>1</tpages></addata></record> |
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| subjects | Acetylation Animal behavior Animals Ants Ants - drug effects Ants - genetics Ants - physiology Behavior, Animal Brain Camponotus Chromatin - metabolism Control Epigenesis, Genetic Forages Formicidae Genes Histone Deacetylase 2 - antagonists & inhibitors Histone Deacetylase 2 - genetics Histone Deacetylase 2 - physiology Histone Deacetylase Inhibitors - pharmacology Histones Inhibitors Insects Labor Narcotics Protein Processing, Post-Translational RESEARCH ARTICLE SUMMARY Ribonucleic acid RNA Social Behavior Social Class Transcriptome |
| title | Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus |
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