Mitomycin against posterior capsular opacification: an experimental study in rabbits
AIMS/BACKGROUND: Posterior capsular opacification is the most common postoperative complication of extracapsular cataract surgery. The purpose of this study was to attempt to inhibit this secondary cataract formation by using mitomycin (an antimitotic drug). METHODS: A solution containing mitomycin...
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| Veröffentlicht in: | British journal of ophthalmology 1996-12, Vol.80 (12), p.1087-1091 |
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| creator | Haus, C M Galand, A L |
| description | AIMS/BACKGROUND: Posterior capsular opacification is the most common postoperative complication of extracapsular cataract surgery. The purpose of this study was to attempt to inhibit this secondary cataract formation by using mitomycin (an antimitotic drug). METHODS: A solution containing mitomycin was used to perform hydrodissection (with a 5 minute pause) during extracapsular lens extraction in rabbits. This way of administration was chosen to reduce as much as possible drug diffusion into the anterior chamber. Heparin was added to the irrigating solution to avoid fibrin formation. Its ability to prevent posterior cataract opacification was also evaluated at the end of the study. The animals were sacrificed 4 or 6 months after surgery. Grading concerning two aspects of secondary cataract (proliferation and fibrosis) was obtained on gross examination. Histological analysis was subsequently performed. RESULTS: This study demonstrated that mitomycin has a significant inhibitory effect on secondary cataract formation (proliferation as well as fibrosis) in rabbits whereas heparin does not seem to have the same effectiveness. CONCLUSION: This work is a preliminary study concerning the use of mitomycin for prevention of posterior capsular opacification. It has proved its effectiveness in rabbits but more in depth studies are still necessary before its application in humans. |
| doi_str_mv | 10.1136/bjo.80.12.1087 |
| format | Article |
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The purpose of this study was to attempt to inhibit this secondary cataract formation by using mitomycin (an antimitotic drug). METHODS: A solution containing mitomycin was used to perform hydrodissection (with a 5 minute pause) during extracapsular lens extraction in rabbits. This way of administration was chosen to reduce as much as possible drug diffusion into the anterior chamber. Heparin was added to the irrigating solution to avoid fibrin formation. Its ability to prevent posterior cataract opacification was also evaluated at the end of the study. The animals were sacrificed 4 or 6 months after surgery. Grading concerning two aspects of secondary cataract (proliferation and fibrosis) was obtained on gross examination. Histological analysis was subsequently performed. RESULTS: This study demonstrated that mitomycin has a significant inhibitory effect on secondary cataract formation (proliferation as well as fibrosis) in rabbits whereas heparin does not seem to have the same effectiveness. CONCLUSION: This work is a preliminary study concerning the use of mitomycin for prevention of posterior capsular opacification. It has proved its effectiveness in rabbits but more in depth studies are still necessary before its application in humans.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.80.12.1087</identifier><identifier>PMID: 9059276</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Animals ; Biological and medical sciences ; Cataract - drug therapy ; Cataract Extraction ; Medical sciences ; Mitomycin - therapeutic use ; Postoperative Complications ; Postoperative Period ; Rabbits ; Recurrence ; Single-Blind Method ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the eye and orbit</subject><ispartof>British journal of ophthalmology, 1996-12, Vol.80 (12), p.1087-1091</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD Dec 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b482t-ab70cef45c7b049f9776ccf70ef3c8d515c555821f432cee5bf5544a63e9c0793</citedby><cites>FETCH-LOGICAL-b482t-ab70cef45c7b049f9776ccf70ef3c8d515c555821f432cee5bf5544a63e9c0793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC505709/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC505709/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2493897$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9059276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haus, C M</creatorcontrib><creatorcontrib>Galand, A L</creatorcontrib><title>Mitomycin against posterior capsular opacification: an experimental study in rabbits</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>AIMS/BACKGROUND: Posterior capsular opacification is the most common postoperative complication of extracapsular cataract surgery. The purpose of this study was to attempt to inhibit this secondary cataract formation by using mitomycin (an antimitotic drug). METHODS: A solution containing mitomycin was used to perform hydrodissection (with a 5 minute pause) during extracapsular lens extraction in rabbits. This way of administration was chosen to reduce as much as possible drug diffusion into the anterior chamber. Heparin was added to the irrigating solution to avoid fibrin formation. Its ability to prevent posterior cataract opacification was also evaluated at the end of the study. The animals were sacrificed 4 or 6 months after surgery. Grading concerning two aspects of secondary cataract (proliferation and fibrosis) was obtained on gross examination. Histological analysis was subsequently performed. RESULTS: This study demonstrated that mitomycin has a significant inhibitory effect on secondary cataract formation (proliferation as well as fibrosis) in rabbits whereas heparin does not seem to have the same effectiveness. CONCLUSION: This work is a preliminary study concerning the use of mitomycin for prevention of posterior capsular opacification. It has proved its effectiveness in rabbits but more in depth studies are still necessary before its application in humans.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cataract - drug therapy</subject><subject>Cataract Extraction</subject><subject>Medical sciences</subject><subject>Mitomycin - therapeutic use</subject><subject>Postoperative Complications</subject><subject>Postoperative Period</subject><subject>Rabbits</subject><subject>Recurrence</subject><subject>Single-Blind Method</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkcGPEyEUxonRrN3VqzeTSfTiYSowMICJB1PX1WRdPaxeyYPCSp0OIzBm-99L06bRkyce-X7vvQ8-hJ4RvCSk61-bTVzKWtMlwVI8QAvCetlSLNRDtMAYi5aQnjxG5zlv6pX2RJyhM4W5oqJfoNvPocTtzoaxgTsIYy7NFHNxKcTUWJjyPEBq4gQ2-GChhDi-aWBs3P1Uma0bCwxNLvN619QRCYwJJT9BjzwM2T09nhfo24fL29XH9vrL1afVu-vWMElLC0Zg6zzjVhjMlFdC9NZ6gZ3vrFxzwi3nXFLiWUetc9x4zhmDvnPK1gd2F-jtYe40m61b2-omwaCnagzSTkcI-l9lDD_0XfytOeYC7_tfHPtT_DW7XPQmzmmsljURAuNOEsEqtTxQNsWck_OnBQTrfQa6ZqBlraneZ1Abnv9t64QfP73qL486ZAuDTzDakE8YZaqTaj-mPWCh5nF_kiH91L3oBNc331daKnVDr75S_b7yrw682W7-Z_EPonatWw</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Haus, C M</creator><creator>Galand, A L</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>19961201</creationdate><title>Mitomycin against posterior capsular opacification: an experimental study in rabbits</title><author>Haus, C M ; Galand, A L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b482t-ab70cef45c7b049f9776ccf70ef3c8d515c555821f432cee5bf5544a63e9c0793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cataract - drug therapy</topic><topic>Cataract Extraction</topic><topic>Medical sciences</topic><topic>Mitomycin - therapeutic use</topic><topic>Postoperative Complications</topic><topic>Postoperative Period</topic><topic>Rabbits</topic><topic>Recurrence</topic><topic>Single-Blind Method</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the eye and orbit</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haus, C M</creatorcontrib><creatorcontrib>Galand, A L</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haus, C M</au><au>Galand, A L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mitomycin against posterior capsular opacification: an experimental study in rabbits</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>80</volume><issue>12</issue><spage>1087</spage><epage>1091</epage><pages>1087-1091</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>AIMS/BACKGROUND: Posterior capsular opacification is the most common postoperative complication of extracapsular cataract surgery. The purpose of this study was to attempt to inhibit this secondary cataract formation by using mitomycin (an antimitotic drug). METHODS: A solution containing mitomycin was used to perform hydrodissection (with a 5 minute pause) during extracapsular lens extraction in rabbits. This way of administration was chosen to reduce as much as possible drug diffusion into the anterior chamber. Heparin was added to the irrigating solution to avoid fibrin formation. Its ability to prevent posterior cataract opacification was also evaluated at the end of the study. The animals were sacrificed 4 or 6 months after surgery. Grading concerning two aspects of secondary cataract (proliferation and fibrosis) was obtained on gross examination. Histological analysis was subsequently performed. RESULTS: This study demonstrated that mitomycin has a significant inhibitory effect on secondary cataract formation (proliferation as well as fibrosis) in rabbits whereas heparin does not seem to have the same effectiveness. CONCLUSION: This work is a preliminary study concerning the use of mitomycin for prevention of posterior capsular opacification. It has proved its effectiveness in rabbits but more in depth studies are still necessary before its application in humans.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>9059276</pmid><doi>10.1136/bjo.80.12.1087</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Cataract - drug therapy Cataract Extraction Medical sciences Mitomycin - therapeutic use Postoperative Complications Postoperative Period Rabbits Recurrence Single-Blind Method Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit |
| title | Mitomycin against posterior capsular opacification: an experimental study in rabbits |
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