Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase

A recently discovered class of endogenous mammalian lipids, branched fatty acid esters of hydroxy fatty acids (FAHFAs), possesses anti-diabetic and anti-inflammatory activities. Here, we identified and validated carboxyl ester lipase (CEL), a pancreatic enzyme hydrolyzing cholesteryl esters and othe...

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Veröffentlicht in:	Biochemistry (Easton) 2016-08, Vol.55 (33), p.4636-4641
Hauptverfasser:	Kolar, Matthew J., Kamat, Siddhesh S., Parsons, William H., Homan, Edwin A., Maher, Tim, Peroni, Odile D., Syed, Ismail, Fjeld, Karianne, Molven, Anders, Kahn, Barbara B., Cravatt, Benjamin F., Saghatelian, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-inflammatory activity Carboxylesterase - metabolism carboxylic ester hydrolases cholesteryl esters dietary fat Esters fatty acid esters Fatty Acids - chemistry hydrolysis hydroxy fatty acids mammals noninsulin-dependent diabetes mellitus pancreatitis Substrate Specificity
Online-Zugang:	Volltext
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