Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel

Voltage-gated proton (Hv1) channels are involved in many physiological processes, such as pH homeostasis and the innate immune response. Zn2+ is an important physiological inhibitor of Hv1. Sperm cells are quiescent in the male reproductive system due to Zn2+ inhibition of Hv1 channels, but become a...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-10, Vol.113 (40), p.E5962-E5971
Hauptverfasser:	Qiu, Feng, Chamberlin, Adam, Watkins, Briana M., Ionescu, Alina, Perez, Marta Elena, Barro-Soria, Rene, González, Carlos, Noskov, Sergei Y., Larsson, H. Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Biological Sciences Female Fluorometry - methods Humans Hydrogen-Ion Concentration Immunity, Innate - genetics Ion Channel Gating - genetics Ion Channels - genetics Ion Channels - metabolism Mutation Patch-Clamp Techniques - methods PNAS Plus Protons Xenopus laevis - metabolism Zinc - chemistry Zinc - metabolism
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