Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling

In recent years the Illumina HumanMethylation450 (HM450) BeadChip has provided a user-friendly platform to profile DNA methylation in human samples. However, HM450 lacked coverage of distal regulatory elements. Illumina have now released the MethylationEPIC (EPIC) BeadChip, with new content specific...

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Veröffentlicht in:	Genome Biology 2016-10, Vol.17 (1), p.208-208, Article 208
Hauptverfasser:	Pidsley, Ruth, Zotenko, Elena, Peters, Timothy J, Lawrence, Mitchell G, Risbridger, Gail P, Molloy, Peter, Van Djik, Susan, Muhlhausler, Beverly, Stirzaker, Clare, Clark, Susan J
Format:	Artikel
Sprache:	eng
Schlagworte:	Complications and side effects Consortia CpG islands CpG Islands - genetics Deoxyribonucleic acid Design Disease DNA DNA fingerprinting DNA methylation DNA Methylation - genetics DNA microarrays DNA probes Enhancer Elements, Genetic - genetics Enhancers Epigenetics Gene expression Genetic diversity genetic variation genome Genome, Human Genomes High-Throughput Nucleotide Sequencing Humans Hybridization loci Methylation microarray technology Oligonucleotide Array Sequence Analysis - methods Prostate cancer Regulatory sequences Researchers Sequence Analysis, DNA - methods Type 2 diabetes
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