No associations of a set of SNPs in the Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinase (MMP) genes with survival of colorectal cancer patients

In this study, we aimed to investigate the associations of genetic variations within select genes functioning in angiogenesis, lymph‐angiogenesis, and metastasis pathways and the risk of outcome in colorectal cancer patients. We followed a two‐stage analysis: First, 381 polymorphisms from 30 genes (...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2016-09, Vol.5 (9), p.2221-2231
Hauptverfasser:	Dan, Lydia A., Werdyani, Salem, Xu, Jingxiong, Shestopaloff, Konstantin, Hyde, Angela, Dicks, Elizabeth, Younghusband, Ban, Green, Jane, Parfrey, Patrick, Xu, Wei, Savas, Sevtap
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Angiogenesis Biomarkers Cancer Chemotherapy Clinical Cancer Research Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - therapy Deoxyribonucleic acid DNA Extracellular matrix Female Genes Genetic diversity Genetic Predisposition to Disease Genetic testing Genotype Humans Interdisciplinary aspects Linkage disequilibrium lymph‐angiogenesis Male Matrix metalloproteinase matrix metalloproteinases Matrix Metalloproteinases - genetics Medical research Metalloproteinase Metastases Metastasis Microsatellite instability Mortality Neoplasm Grading Neoplasm Metastasis Neoplasm Staging Neovascularization, Pathologic - genetics Neutrophil collagenase Original Research overall survival Patients Polymorphism, Single Nucleotide Prognosis Proportional Hazards Models Replication Single-nucleotide polymorphism SNPs Statistical analysis Studies Survival Survival analysis Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics vascular endothelial growth factors VEGFs
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