The importance of evolutionarily conserved C‐terminal basic residues for the stability of proapoptotic Bax protein

Bax is a protein that promotes apoptosis (a form of cell death). The atomistic details of the mechanism by which Bax is activated during apoptosis remain a subject of debate. C‐terminal basic residues in the sequence of Bax show remarkable conservation across a variety of species. The role of these...

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Veröffentlicht in:	FEBS open bio 2016-10, Vol.6 (10), p.976-986
1. Verfasser:	Rosas‐Trigueros, Jorge L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bax protein Cell death Conserved sequence High temperature molecular dynamics Mutation protein stability Proteins Simulation
Online-Zugang:	Volltext
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