Red blood cell antioxidant enzymes in age-related macular degeneration
AIMS/BACKGROUND: Oxidative damage has been proposed to be involved in the pathogenesis of age-related macular degeneration (ARMD). The purpose of this study was to evaluate whether red blood cell antioxidant enzyme activity correlates with severity of aging maculopathy in affected individuals. METHO...
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| Veröffentlicht in: | British journal of ophthalmology 1996-05, Vol.80 (5), p.445-450 |
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| container_title | British journal of ophthalmology |
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| creator | De La Paz, M A Zhang, J Fridovich, I |
| description | AIMS/BACKGROUND: Oxidative damage has been proposed to be involved in the pathogenesis of age-related macular degeneration (ARMD). The purpose of this study was to evaluate whether red blood cell antioxidant enzyme activity correlates with severity of aging maculopathy in affected individuals. METHODS: Blood samples were obtained from 54 patients with varying severity of aging maculopathy and 12 similarly aged individuals with normal ophthalmoscopic examination. Macular findings were graded according to a modification of the method described for the Age-Related Eye Disease Study. (AREDS). The activities of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase, glutathione peroxidase, and glutathione reductase were measured in red blood cells. Haemoglobin content of whole blood was measured, and enzyme activity was determined per mg haemoglobin. RESULTS: Multiple regression analysis and ordinal logistic regression analysis were performed to determine whether antioxidant enzyme activity was associated with severity of ARMD. No significant association between disease severity of ARMD and antioxidant enzyme activity was identified for any of the enzymes. CONCLUSION: These results do not provide evidence for a relation between oxidative stress, as measured by antioxidant enzyme activity in red blood cells, and disease severity in ARMD. |
| doi_str_mv | 10.1136/bjo.80.5.445 |
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The purpose of this study was to evaluate whether red blood cell antioxidant enzyme activity correlates with severity of aging maculopathy in affected individuals. METHODS: Blood samples were obtained from 54 patients with varying severity of aging maculopathy and 12 similarly aged individuals with normal ophthalmoscopic examination. Macular findings were graded according to a modification of the method described for the Age-Related Eye Disease Study. (AREDS). The activities of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase, glutathione peroxidase, and glutathione reductase were measured in red blood cells. Haemoglobin content of whole blood was measured, and enzyme activity was determined per mg haemoglobin. RESULTS: Multiple regression analysis and ordinal logistic regression analysis were performed to determine whether antioxidant enzyme activity was associated with severity of ARMD. No significant association between disease severity of ARMD and antioxidant enzyme activity was identified for any of the enzymes. CONCLUSION: These results do not provide evidence for a relation between oxidative stress, as measured by antioxidant enzyme activity in red blood cells, and disease severity in ARMD.</description><identifier>ISSN: 0007-1161</identifier><identifier>EISSN: 1468-2079</identifier><identifier>DOI: 10.1136/bjo.80.5.445</identifier><identifier>PMID: 8695567</identifier><identifier>CODEN: BJOPAL</identifier><language>eng</language><publisher>BMA House, Tavistock Square, London, WC1H 9JR: BMJ Publishing Group Ltd</publisher><subject>Aged ; Biological and medical sciences ; Case-Control Studies ; Erythrocytes - enzymology ; Female ; Glucosephosphate Dehydrogenase - blood ; Glutathione Peroxidase - blood ; Hemoglobinometry ; Humans ; Macular Degeneration - blood ; Macular Degeneration - enzymology ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; Oxidoreductases - blood ; Regression Analysis ; Retinopathies ; Superoxide Dismutase - blood</subject><ispartof>British journal of ophthalmology, 1996-05, Vol.80 (5), p.445-450</ispartof><rights>1996 INIST-CNRS</rights><rights>Copyright BMJ Publishing Group LTD May 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b505t-c5b45766aab2b150ace6db734072b7daf66facbc8568e64f24c04b745c101e763</citedby><cites>FETCH-LOGICAL-b505t-c5b45766aab2b150ace6db734072b7daf66facbc8568e64f24c04b745c101e763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC505497/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC505497/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3080881$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8695567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De La Paz, M A</creatorcontrib><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Fridovich, I</creatorcontrib><title>Red blood cell antioxidant enzymes in age-related macular degeneration</title><title>British journal of ophthalmology</title><addtitle>Br J Ophthalmol</addtitle><description>AIMS/BACKGROUND: Oxidative damage has been proposed to be involved in the pathogenesis of age-related macular degeneration (ARMD). The purpose of this study was to evaluate whether red blood cell antioxidant enzyme activity correlates with severity of aging maculopathy in affected individuals. METHODS: Blood samples were obtained from 54 patients with varying severity of aging maculopathy and 12 similarly aged individuals with normal ophthalmoscopic examination. Macular findings were graded according to a modification of the method described for the Age-Related Eye Disease Study. (AREDS). The activities of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase, glutathione peroxidase, and glutathione reductase were measured in red blood cells. Haemoglobin content of whole blood was measured, and enzyme activity was determined per mg haemoglobin. RESULTS: Multiple regression analysis and ordinal logistic regression analysis were performed to determine whether antioxidant enzyme activity was associated with severity of ARMD. No significant association between disease severity of ARMD and antioxidant enzyme activity was identified for any of the enzymes. CONCLUSION: These results do not provide evidence for a relation between oxidative stress, as measured by antioxidant enzyme activity in red blood cells, and disease severity in ARMD.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Erythrocytes - enzymology</subject><subject>Female</subject><subject>Glucosephosphate Dehydrogenase - blood</subject><subject>Glutathione Peroxidase - blood</subject><subject>Hemoglobinometry</subject><subject>Humans</subject><subject>Macular Degeneration - blood</subject><subject>Macular Degeneration - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Oxidoreductases - blood</subject><subject>Regression Analysis</subject><subject>Retinopathies</subject><subject>Superoxide Dismutase - blood</subject><issn>0007-1161</issn><issn>1468-2079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1v1DAQxS0EKkvhxhUpEgguZLETf-2BA6wooFZFqvg4WmNnsnhJ7GInqOWvx2VXK-DAaWS93xu_0SPkIaNLxlr5wm7jUtOlWHIubpEF41LXDVWr22RBKVU1Y5LdJfdy3pZnI5k6IkdaroSQakFOLrCr7BBjVzkchgrC5OOV78qsMPy8HjFXPlSwwTrhAFOhR3DzAKnqcIMBExRDuE_u9DBkfLCfx-TTyZuP63f12Ye379evzmorqJhqJywXSkoA21gmKDiUnVUtp6qxqoNeyh6cdVpIjZL3DXeUW8WFY5Shku0xebnbeznbETuHYUowmMvkR0jXJoI3fyvBfzWb-MOU7_lKFf_TvT_F7zPmyYw-3xwOAeOcjdIl1Uq0BXz8D7iNcwrlNsOUorRV7e91z3eUSzHnhP0hCaPmphxTyjGaGmFKOQV_9Gf6A7xvo-hP9jpkB0OfIDifD1hLNdWaFazeYT5PeHWQIX0zZYkS5vzz2qjT5vTL6-bCnBf-2Y634_b_AX8BYmezuw</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>De La Paz, M A</creator><creator>Zhang, J</creator><creator>Fridovich, I</creator><general>BMJ Publishing Group Ltd</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19960501</creationdate><title>Red blood cell antioxidant enzymes in age-related macular degeneration</title><author>De La Paz, M A ; Zhang, J ; Fridovich, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b505t-c5b45766aab2b150ace6db734072b7daf66facbc8568e64f24c04b745c101e763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Erythrocytes - enzymology</topic><topic>Female</topic><topic>Glucosephosphate Dehydrogenase - blood</topic><topic>Glutathione Peroxidase - blood</topic><topic>Hemoglobinometry</topic><topic>Humans</topic><topic>Macular Degeneration - blood</topic><topic>Macular Degeneration - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Oxidoreductases - blood</topic><topic>Regression Analysis</topic><topic>Retinopathies</topic><topic>Superoxide Dismutase - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De La Paz, M A</creatorcontrib><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Fridovich, I</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - Health & Medical Complete保健、医学与药学数据库</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De La Paz, M A</au><au>Zhang, J</au><au>Fridovich, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red blood cell antioxidant enzymes in age-related macular degeneration</atitle><jtitle>British journal of ophthalmology</jtitle><addtitle>Br J Ophthalmol</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>80</volume><issue>5</issue><spage>445</spage><epage>450</epage><pages>445-450</pages><issn>0007-1161</issn><eissn>1468-2079</eissn><coden>BJOPAL</coden><abstract>AIMS/BACKGROUND: Oxidative damage has been proposed to be involved in the pathogenesis of age-related macular degeneration (ARMD). The purpose of this study was to evaluate whether red blood cell antioxidant enzyme activity correlates with severity of aging maculopathy in affected individuals. METHODS: Blood samples were obtained from 54 patients with varying severity of aging maculopathy and 12 similarly aged individuals with normal ophthalmoscopic examination. Macular findings were graded according to a modification of the method described for the Age-Related Eye Disease Study. (AREDS). The activities of superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase, glutathione peroxidase, and glutathione reductase were measured in red blood cells. Haemoglobin content of whole blood was measured, and enzyme activity was determined per mg haemoglobin. RESULTS: Multiple regression analysis and ordinal logistic regression analysis were performed to determine whether antioxidant enzyme activity was associated with severity of ARMD. No significant association between disease severity of ARMD and antioxidant enzyme activity was identified for any of the enzymes. CONCLUSION: These results do not provide evidence for a relation between oxidative stress, as measured by antioxidant enzyme activity in red blood cells, and disease severity in ARMD.</abstract><cop>BMA House, Tavistock Square, London, WC1H 9JR</cop><pub>BMJ Publishing Group Ltd</pub><pmid>8695567</pmid><doi>10.1136/bjo.80.5.445</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biological and medical sciences Case-Control Studies Erythrocytes - enzymology Female Glucosephosphate Dehydrogenase - blood Glutathione Peroxidase - blood Hemoglobinometry Humans Macular Degeneration - blood Macular Degeneration - enzymology Male Medical sciences Middle Aged Ophthalmology Oxidoreductases - blood Regression Analysis Retinopathies Superoxide Dismutase - blood |
| title | Red blood cell antioxidant enzymes in age-related macular degeneration |
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