Mastering variation: variance components and personalised medicine
Various sources of variation in observed response in clinical trials and clinical practice are considered, and ways in which the corresponding components of variation might be estimated are discussed. Although the issues have been generally well‐covered in the statistical literature, they seem to be...
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| Veröffentlicht in: | Statistics in medicine 2016-03, Vol.35 (7), p.966-977 |
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| creator | Senn, Stephen |
| description | Various sources of variation in observed response in clinical trials and clinical practice are considered, and ways in which the corresponding components of variation might be estimated are discussed. Although the issues have been generally well‐covered in the statistical literature, they seem to be poorly understood in the medical literature and even the statistical literature occasionally shows some confusion. To increase understanding and communication, some simple graphical approaches to illustrating issues are proposed. It is also suggested that reducing variation in medical practice might make as big a contribution to improving health outcome as personalising its delivery according to the patient. It is concluded that the common belief that there is a strong personal element in response to treatment is not based on sound statistical evidence. © 2015 The Authors. Statistics in Medicine published by John Wiley & Sons Ltd. |
| doi_str_mv | 10.1002/sim.6739 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0277-6715 |
| ispartof | Statistics in medicine, 2016-03, Vol.35 (7), p.966-977 |
| issn | 0277-6715 1097-0258 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Analysis of Variance Asthma - physiopathology Asthma - therapy Biostatistics Clinical medicine Clinical trials Clinical Trials as Topic - statistics & numerical data Communication components of variation Computer Graphics Computer Simulation Cross-Over Studies cross-over trials Forced Expiratory Volume Humans n-of-1 trials personalised medicine Precision Medicine - statistics & numerical data random effects Randomized Controlled Trials as Topic - statistics & numerical data Special Issue Paper Special Issue Papers Tonsillectomy - statistics & numerical data |
| title | Mastering variation: variance components and personalised medicine |
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