An RNA-seq-based Gene Expression Profiling of Radiation-induced Tumorigenic Mammary Epithelial Cells

Immortality and tumorigenicity are two distinct characteristics of cancers. Immortalization has been suggested to precede tumorigenesis. To understand the molecular mechanisms of tumorigenicity and cancer progression in mammary epithelium, we established a tumorigenic cell model by means of heavy-io...

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Veröffentlicht in:	Genomics, proteomics & bioinformatics proteomics & bioinformatics, 2012-12, Vol.10 (6), p.326-335
Hauptverfasser:	Ma, Lina, Nie, Linghu, Liu, Jing, Zhang, Bing, Song, Shuhui, Sun, Min, Yang, Jin, Yang, Yadong, Fang, Xiangdong, Hu, Songnian, Zhao, Yongliang, Yu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Bioinformatics Breast cancer Breast Neoplasms Breast Neoplasms - genetics Cancer carcinogenesis Cell culture Cell Line Cell Line, Tumor Cell Transformation, Neoplastic Cell Transformation, Neoplastic - genetics cytology Data processing Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelium Exons Gene Expression Gene Expression Profiling gene expression regulation Gene Regulatory Networks genes genetics High-Throughput Nucleotide Sequencing Humans Immortality Immortalization Mammary gland Mammary Glands, Human Mammary Glands, Human - cytology Mammary Glands, Human - metabolism Mammary Glands, Human - pathology metabolism Molecular modelling neoplasms Neoplasms, Radiation-Induced Neoplasms, Radiation-Induced - genetics NGS Original Research pathology proteomics Radiation reverse transcriptase polymerase chain reaction RNA RNA - genetics RNA-seq telomerase Telomerase - genetics telomerase reverse transcriptase transcriptomics Tumorigenesis Tumorigenicity 乳腺上皮细胞人端粒酶逆转录酶基因表达谱定量RT-PCR 差异表达基因细胞模型致癌性重离子辐射
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