Codon influence on protein expression in E. coli correlates with mRNA levels

Degeneracy in the genetic code, which enables a single protein to be encoded by a multitude of synonymous gene sequences, has an important role in regulating protein expression, but substantial uncertainty exists concerning the details of this phenomenon. Here we analyse the sequence features influe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature (London) 2016-01, Vol.529 (7586), p.358-363
Hauptverfasser:	Boël, Grégory, Letso, Reka, Neely, Helen, Price, W. Nicholson, Wong, Kam-Ho, Su, Min, Luff, Jon D., Valecha, Mayank, Everett, John K., Acton, Thomas B., Xiao, Rong, Montelione, Gaetano T., Aalberts, Daniel P., Hunt, John F.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326 631/337/574 631/553/2695 631/61 Biochemistry, Molecular Biology Biotechnology Codon Codon - genetics DNA-Directed RNA Polymerases - metabolism E coli Escherichia coli Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - biosynthesis Escherichia coli Proteins - genetics Gene Expression Regulation, Bacterial - genetics Generalized linear models Genes Genes, Synthetic - genetics Genetic aspects Half-Life Humanities and Social Sciences Kinetics Life Sciences Logistic Models Messenger RNA Microbiological research Models, Genetic Molecular Sequence Data multidisciplinary Odds Ratio Peptide Chain Elongation, Translational Physiology Protein Biosynthesis - genetics Protein expression Proteins Quantitative Methods RNA Folding RNA polymerase RNA Stability RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Science Transcription, Genetic - genetics Transfer RNA Viral Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!