Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial
Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass. We conducted a randomised double-blind, parallel, placebo control...
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| creator | Ng Tang Fui, Mark Prendergast, Luke A Dupuis, Philippe Raval, Manjri Strauss, Boyd J Zajac, Jeffrey D Grossmann, Mathis |
| description | Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass.
We conducted a randomised double-blind, parallel, placebo controlled trial at a tertiary referral centre. A total of 100 obese men (body mass index ≥ 30 kg/m
) with a total testosterone level of or below 12 nmol/L and a median age of 53 years (interquartile range 47-60) receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of 10-weekly intramuscular testosterone undecanoate (n = 49, cases) or matching placebo (n = 51, controls). The main outcome measures were the between-group difference in fat and lean mass by dual-energy X-ray absorptiometry, and visceral fat area (computed tomography).
A total of 82 men completed the study. At study end, compared to controls, cases had greater reductions in fat mass, with a mean adjusted between-group difference (MAD) of -2.9 kg (-5.7 to -0.2; P = 0.04), and in visceral fat (MAD -2678 mm
; -5180 to -176; P = 0.04). Although both groups lost the same lean mass following VLED (cases -3.9 kg (-5.3 to -2.6); controls -4.8 kg (-6.2 to -3.5), P = 0.36), cases regained lean mass (3.3 kg (1.9 to 4.7), P |
| doi_str_mv | 10.1186/s12916-016-0700-9 |
| format | Article |
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We conducted a randomised double-blind, parallel, placebo controlled trial at a tertiary referral centre. A total of 100 obese men (body mass index ≥ 30 kg/m
) with a total testosterone level of or below 12 nmol/L and a median age of 53 years (interquartile range 47-60) receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of 10-weekly intramuscular testosterone undecanoate (n = 49, cases) or matching placebo (n = 51, controls). The main outcome measures were the between-group difference in fat and lean mass by dual-energy X-ray absorptiometry, and visceral fat area (computed tomography).
A total of 82 men completed the study. At study end, compared to controls, cases had greater reductions in fat mass, with a mean adjusted between-group difference (MAD) of -2.9 kg (-5.7 to -0.2; P = 0.04), and in visceral fat (MAD -2678 mm
; -5180 to -176; P = 0.04). Although both groups lost the same lean mass following VLED (cases -3.9 kg (-5.3 to -2.6); controls -4.8 kg (-6.2 to -3.5), P = 0.36), cases regained lean mass (3.3 kg (1.9 to 4.7), P < 0.001) during weight maintenance, in contrast to controls (0.8 kg (-0.7 to 2.3), P = 0.29) so that, at study end, cases had an attenuated reduction in lean mass compared to controls (MAD 3.4 kg (1.3 to 5.5), P = 0.002).
While dieting men receiving placebo lost both fat and lean mass, the weight loss with testosterone treatment was almost exclusively due to loss of body fat.
clinicaltrials.gov, identifier NCT01616732 , registration date: June 8, 2012.</description><identifier>ISSN: 1741-7015</identifier><identifier>EISSN: 1741-7015</identifier><identifier>DOI: 10.1186/s12916-016-0700-9</identifier><identifier>PMID: 27716209</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Absorptiometry, Photon ; Accelerometers ; Adipose Tissue - drug effects ; Analysis ; Androgens ; Body composition ; Body Composition - drug effects ; Body fat ; Body mass index ; Body Weight - drug effects ; Clinical trials ; Combined Modality Therapy - methods ; Diet ; Diet, Reducing - methods ; Double-Blind Method ; Gastrointestinal surgery ; Health aspects ; Hemoglobin ; Humans ; Immunoassay ; Low-calorie diet ; Male ; Middle Aged ; Obesity ; Obesity - diet therapy ; Obesity - drug therapy ; Peptides ; Physiological aspects ; Prostate ; Questionnaires ; Testosterone ; Testosterone - administration & dosage ; Testosterone - analogs & derivatives ; Weight control</subject><ispartof>BMC medicine, 2016-10, Vol.14 (1), p.153-153, Article 153</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-2855b92158e89a3d7e0ecb374f8caa68da11f3ab6ae78843380812715285a7563</citedby><cites>FETCH-LOGICAL-c525t-2855b92158e89a3d7e0ecb374f8caa68da11f3ab6ae78843380812715285a7563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054608/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054608/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27716209$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng Tang Fui, Mark</creatorcontrib><creatorcontrib>Prendergast, Luke A</creatorcontrib><creatorcontrib>Dupuis, Philippe</creatorcontrib><creatorcontrib>Raval, Manjri</creatorcontrib><creatorcontrib>Strauss, Boyd J</creatorcontrib><creatorcontrib>Zajac, Jeffrey D</creatorcontrib><creatorcontrib>Grossmann, Mathis</creatorcontrib><title>Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial</title><title>BMC medicine</title><addtitle>BMC Med</addtitle><description>Whether testosterone treatment has benefits on body composition over and above caloric restriction in men is unknown. We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass.
We conducted a randomised double-blind, parallel, placebo controlled trial at a tertiary referral centre. A total of 100 obese men (body mass index ≥ 30 kg/m
) with a total testosterone level of or below 12 nmol/L and a median age of 53 years (interquartile range 47-60) receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of 10-weekly intramuscular testosterone undecanoate (n = 49, cases) or matching placebo (n = 51, controls). The main outcome measures were the between-group difference in fat and lean mass by dual-energy X-ray absorptiometry, and visceral fat area (computed tomography).
A total of 82 men completed the study. At study end, compared to controls, cases had greater reductions in fat mass, with a mean adjusted between-group difference (MAD) of -2.9 kg (-5.7 to -0.2; P = 0.04), and in visceral fat (MAD -2678 mm
; -5180 to -176; P = 0.04). Although both groups lost the same lean mass following VLED (cases -3.9 kg (-5.3 to -2.6); controls -4.8 kg (-6.2 to -3.5), P = 0.36), cases regained lean mass (3.3 kg (1.9 to 4.7), P < 0.001) during weight maintenance, in contrast to controls (0.8 kg (-0.7 to 2.3), P = 0.29) so that, at study end, cases had an attenuated reduction in lean mass compared to controls (MAD 3.4 kg (1.3 to 5.5), P = 0.002).
While dieting men receiving placebo lost both fat and lean mass, the weight loss with testosterone treatment was almost exclusively due to loss of body fat.
clinicaltrials.gov, identifier NCT01616732 , registration date: June 8, 2012.</description><subject>Absorptiometry, Photon</subject><subject>Accelerometers</subject><subject>Adipose Tissue - drug effects</subject><subject>Analysis</subject><subject>Androgens</subject><subject>Body composition</subject><subject>Body Composition - drug effects</subject><subject>Body fat</subject><subject>Body mass index</subject><subject>Body Weight - drug effects</subject><subject>Clinical trials</subject><subject>Combined Modality Therapy - methods</subject><subject>Diet</subject><subject>Diet, Reducing - methods</subject><subject>Double-Blind Method</subject><subject>Gastrointestinal surgery</subject><subject>Health aspects</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Low-calorie diet</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - diet therapy</subject><subject>Obesity - drug therapy</subject><subject>Peptides</subject><subject>Physiological aspects</subject><subject>Prostate</subject><subject>Questionnaires</subject><subject>Testosterone</subject><subject>Testosterone - administration & dosage</subject><subject>Testosterone - analogs & derivatives</subject><subject>Weight control</subject><issn>1741-7015</issn><issn>1741-7015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkt9rFDEQxxdRbD39A3yRgCB92ZrsbjZZH4RS6g8o-KLPYTY76aVkkzPJFe7B_91sr9Y7MWHIMPl8J5lhquo1o-eMyf59Ys3A-pouJiithyfVKRMdqwVl_OmBf1K9SOmW0oYL0T2vThohWN_Q4bT6dWUM6pxIMCRjyiFljMEjyREhz-gzCZ6MYdoRA5mAn4hD8GSGlIj1JIyYkBRuwYCsd5ugwYVoNZks5g8lFosozDbhRHTwOQbnipujBfeyembAJXz1cK6qH5-uvl9-qa-_ff56eXFda97wXDeS83FoGJcoB2gngRT12IrOSA3QywkYMy2MPaCQsmtbSSVrBONFCIL37ar6uM-72Y4zTrqUFcGpTbQzxJ0KYNXxjbdrdRPuFKe866ksCc4eEsTwc1v6pEpBGp0Dj2GbFJMtbwcq-7agb_9Bb8M2-lLePVVWJ4a_1A04VNabUN7VS1J10fVcdpSVQlbV-X-osiecbWkmGlviR4J3B4I1gsvrFNw22-DTMcj2oI4hpYjmsRmMqmW41H64FF2sDJda_vzmsIuPij_T1P4G7qzI8g</recordid><startdate>20161007</startdate><enddate>20161007</enddate><creator>Ng Tang Fui, Mark</creator><creator>Prendergast, Luke A</creator><creator>Dupuis, Philippe</creator><creator>Raval, Manjri</creator><creator>Strauss, Boyd J</creator><creator>Zajac, Jeffrey D</creator><creator>Grossmann, Mathis</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161007</creationdate><title>Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial</title><author>Ng Tang Fui, Mark ; 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We hypothesised that testosterone treatment augments diet-induced loss of fat mass and prevents loss of muscle mass.
We conducted a randomised double-blind, parallel, placebo controlled trial at a tertiary referral centre. A total of 100 obese men (body mass index ≥ 30 kg/m
) with a total testosterone level of or below 12 nmol/L and a median age of 53 years (interquartile range 47-60) receiving 10 weeks of a very low energy diet (VLED) followed by 46 weeks of weight maintenance were randomly assigned at baseline to 56 weeks of 10-weekly intramuscular testosterone undecanoate (n = 49, cases) or matching placebo (n = 51, controls). The main outcome measures were the between-group difference in fat and lean mass by dual-energy X-ray absorptiometry, and visceral fat area (computed tomography).
A total of 82 men completed the study. At study end, compared to controls, cases had greater reductions in fat mass, with a mean adjusted between-group difference (MAD) of -2.9 kg (-5.7 to -0.2; P = 0.04), and in visceral fat (MAD -2678 mm
; -5180 to -176; P = 0.04). Although both groups lost the same lean mass following VLED (cases -3.9 kg (-5.3 to -2.6); controls -4.8 kg (-6.2 to -3.5), P = 0.36), cases regained lean mass (3.3 kg (1.9 to 4.7), P < 0.001) during weight maintenance, in contrast to controls (0.8 kg (-0.7 to 2.3), P = 0.29) so that, at study end, cases had an attenuated reduction in lean mass compared to controls (MAD 3.4 kg (1.3 to 5.5), P = 0.002).
While dieting men receiving placebo lost both fat and lean mass, the weight loss with testosterone treatment was almost exclusively due to loss of body fat.
clinicaltrials.gov, identifier NCT01616732 , registration date: June 8, 2012.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27716209</pmid><doi>10.1186/s12916-016-0700-9</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC medicine, 2016-10, Vol.14 (1), p.153-153, Article 153 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Absorptiometry, Photon Accelerometers Adipose Tissue - drug effects Analysis Androgens Body composition Body Composition - drug effects Body fat Body mass index Body Weight - drug effects Clinical trials Combined Modality Therapy - methods Diet Diet, Reducing - methods Double-Blind Method Gastrointestinal surgery Health aspects Hemoglobin Humans Immunoassay Low-calorie diet Male Middle Aged Obesity Obesity - diet therapy Obesity - drug therapy Peptides Physiological aspects Prostate Questionnaires Testosterone Testosterone - administration & dosage Testosterone - analogs & derivatives Weight control |
| title | Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial |
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