Disruption of ArhGAP15 results in hyperactive Rac1, affects the architecture and function of hippocampal inhibitory neurons and causes cognitive deficits

During brain development, the small GTPases Rac1/Rac3 play key roles in neuronal migration, neuritogenesis, synaptic formation and plasticity, via control of actin cytoskeleton dynamic. Their activity is positively and negatively regulated by GEFs and GAPs molecules, respectively. However their in v...

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Veröffentlicht in:	Scientific reports 2016-10, Vol.6 (1), p.34877-34877, Article 34877
Hauptverfasser:	Zamboni, Valentina, Armentano, Maria, Sarò, Gabriella, Ciraolo, Elisa, Ghigo, Alessandra, Germena, Giulia, Umbach, Alessandro, Valnegri, Pamela, Passafaro, Maria, Carabelli, Valentina, Gavello, Daniela, Bianchi, Veronica, D’Adamo, Patrizia, de Curtis, Ivan, El-Assawi, Nadia, Mauro, Alessandro, Priano, Lorenzo, Ferri, Nicola, Hirsch, Emilio, Merlo, Giorgio R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/51 14/19 631/378/1595 631/378/2571 64/60 Actin Animals Axonogenesis Behavior, Animal - physiology Cell migration Cell Movement - genetics Cells, Cultured Cognition Disorders - etiology Cognition Disorders - genetics Cognitive ability Cytoskeleton Dentate gyrus Female Firing pattern Gene Expression Regulation, Developmental GTPase-activating protein GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Hippocampus Hippocampus - pathology Hippocampus - physiopathology Humanities and Social Sciences Interneurons - pathology Male Memory, Short-Term - physiology Mice, Mutant Strains multidisciplinary Neural coding Neurons - pathology Neurons - physiology Neuropeptides - genetics Neuropeptides - metabolism Pyramidal cells rac GTP-Binding Proteins - genetics rac GTP-Binding Proteins - metabolism rac1 GTP-Binding Protein - genetics rac1 GTP-Binding Protein - metabolism Rac1 protein Rats Rodents Science Synapses Synaptic plasticity Synchronization
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