Gap junction-mediated transfer of miR-145-5p from microvascular endothelial cells to colon cancer cells inhibits angiogenesis

Gap junctional communication between cancer cells and blood capillary cells is crucial to tumor growth and invasion. Gap junctions may transfer microRNAs (miRs) among cells. Here, we explore the impact of such a transfer in co-culture assays, using the antitumor miR-145 as an example. The SW480 colo...

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Veröffentlicht in:	Oncotarget 2016-05, Vol.7 (19), p.28160-28168
Hauptverfasser:	Thuringer, Dominique, Jego, Gaetan, Berthenet, Kevin, Hammann, Arlette, Solary, Eric, Garrido, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell Communication - physiology Cell Line, Tumor Cellular Biology Coculture Techniques Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Endothelial Cells - metabolism Gap Junctions - metabolism Humans Life Sciences MicroRNAs - metabolism Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Research Paper
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