Cell painting with an engineered EPCR to augment the protein C system

Summary The protein C (PC) system conveys beneficial anticoagulant and cytoprotective effects in numerous in vivo disease models. The endothelial protein C receptor (EPCR) plays a central role in these pathways as cofactor for PC activation and by enhancing activated protein C (APC)-mediated proteas...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Thrombosis and haemostasis 2015, Vol.113 (6), p.1144-1155
Hauptverfasser:	Bouwens, Eveline A. M., Stavenuiter, Fabian, Mosnier, Laurent O.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Antigens, CD - genetics Antigens, CD - metabolism Biological Availability Caveolae - metabolism Caveolin 1 - metabolism Cell Compartmentation Cell Membrane - metabolism Coagulation and Fibrinolysis Dose-Response Relationship, Drug Endothelial Cells - metabolism Endothelial Protein C Receptor Enzyme Activation Glycosylphosphatidylinositols - metabolism HEK293 Cells Humans Membrane Microdomains - metabolism Phosphorylation Protein Binding Protein C - metabolism Protein Engineering Protein Processing, Post-Translational Proto-Oncogene Proteins c-akt - metabolism Receptor, PAR-1 - metabolism Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Recombinant Fusion Proteins - metabolism RNA Interference RNA, Small Interfering - genetics Tetradecanoylphorbol Acetate - pharmacology Transduction, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!