Activation Mechanism of the Bacteroides fragilis Cysteine Peptidase, Fragipain

Enterotoxigenic Bacteroides fragilis produces a secreted metalloprotease known as B. fragilis toxin (BFT), which contributes to anaerobic sepsis, colitis, and colonic malignancy in mouse models of disease. A C11 family cysteine protease, fragipain (Fpn), directly activates BFT in the B. fragilis cel...

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Veröffentlicht in:	Biochemistry (Easton) 2016-07, Vol.55 (29), p.4077-4084
Hauptverfasser:	Herrou, Julien, Choi, Vivian M, Bubeck Wardenburg, Juliane, Crosson, Sean
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Bacterial Toxins - chemistry Bacterial Toxins - genetics Bacterial Toxins - metabolism Bacteroides fragilis - enzymology Bacteroides fragilis - genetics Bacteroides fragilis - pathogenicity Catalytic Domain Cysteine Proteases - chemistry Cysteine Proteases - genetics Cysteine Proteases - metabolism Enzyme Activation Enzyme Precursors - chemistry Enzyme Precursors - genetics Enzyme Precursors - metabolism Kinetics Metalloendopeptidases - chemistry Metalloendopeptidases - genetics Metalloendopeptidases - metabolism Metalloproteases - chemistry Metalloproteases - genetics Metalloproteases - metabolism Mice Models, Molecular Mutagenesis, Site-Directed Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Substrate Specificity
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