Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans

Misfolded alpha-synuclein (AS) and other neurodegenerative disorder proteins display prion-like transmission of protein aggregation. Factors responsible for the initiation of AS aggregation are unknown. To evaluate the role of amyloid proteins made by the microbiota we exposed aged rats and transgen...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2016-10, Vol.6 (1), p.34477-34477, Article 34477
Hauptverfasser:	Chen, Shu G., Stribinskis, Vilius, Rane, Madhavi J., Demuth, Donald R., Gozal, Evelyne, Roberts, Andrew M., Jagadapillai, Rekha, Liu, Ruolan, Choe, Kyonghwan, Shivakumar, Bhooma, Son, Francheska, Jin, Shunying, Kerber, Richard, Adame, Anthony, Masliah, Eliezer, Friedland, Robert P.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/51 59 692/617/375 692/617/375/132 82 82/1 82/51 Bacteria Body weight E coli Gastrointestinal tract Genes Gliosis Humanities and Social Sciences Immune system Innate immunity Interleukin 6 multidisciplinary Nematodes Neurodegenerative diseases Prion protein Protein interaction Protein seeding Proteins Retina Science Science (multidisciplinary) Synuclein TLR2 protein Toll-like receptors Tumor necrosis factor β-Amyloid
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!