Attenuation of synaptic toxicity and MARK4/PAR1-mediated Tau phosphorylation by methylene blue for Alzheimer’s disease treatment

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by genotypic and phenotypic heterogeneity. Critical components of the two AD pathological pathways, Aβ-amyloidosis and Tauopathy, have been considered as therapeutic targets. Among them, much effort is focused on aberrant Tau phos...

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Veröffentlicht in:	Scientific reports 2016-10, Vol.6 (1), p.34784, Article 34784
Hauptverfasser:	Sun, Wenchao, Lee, Seongsoo, Huang, Xiaoran, Liu, Song, Inayathullah, Mohammed, Kim, Kwang-Min, Tang, Hongxiang, Ashford, J. Wesson, Rajadas, Jayakumar
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/275 631/92/609 Alzheimer's disease Amyloidosis Blood-brain barrier Heterogeneity Humanities and Social Sciences Kinases Larvae Medical treatment Methylene blue multidisciplinary Neurodegenerative diseases Phenothiazine Phosphorylation Proteasomes Protein folding Science Tau protein Toxicity Ubiquitin
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