Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone
Background Ptycholobium is a genus related to Tephrosia which comprises only three species. Compared to Tephrosia , which has been phytochemically and pharmacologically studied, Ptycholobium species have only few or no reports on their chemical constituents. Moreover, no studies on the cytotoxic act...
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| creator | Ngnintedo, Dominique Fotso, Ghislain W. Kuete, Victor Nana, Frederic Sandjo, Louis P. Karaosmanoğlu, Oğuzhan Sivas, Hülya Keumedjio, Felix Kirsch, Gilbert Ngadjui, Bonaventure T. Andrae-Marobela, Kerstin |
| description | Background
Ptycholobium
is a genus related to
Tephrosia
which comprises only three species. Compared to
Tephrosia
, which has been phytochemically and pharmacologically studied,
Ptycholobium
species have only few or no reports on their chemical constituents. Moreover, no studies on the cytotoxic activities of its secondary metabolites have been previously documented.
Results
From the non polar fractions of the roots bark of
Ptycholobium contortum
(syn
Tephrosia contorta
), two new pterocarpans: seputhecarpan C
1
and seputhecarpan D
2
and a new pyrone derivative, ptycholopyrone A
3
were isolated. Alongside, five known compounds identified as 3-α,α-dimethylallyl-4-methoxy-6-styryl-α-pyrone or mundulea lactone
4
, glyasperin F
5
, seputhecarpan A
6
, seputheisoflavone
7
and 5-
O
-methyl-myo-inositol or sequoyitol
8
were also obtained. Their structures were established by the mean means of spectroscopic data in conjunction to those reported in literature. The NMR assignment of the major compound mundulea lactone
4
is revised in this paper. In addition, the cytotoxicity of the isolated metabolites was evaluated on two lung cancer cell lines A549 and SPC212.
8
was not active while compounds
1, 2, 4–7
displayed antiproliferative effects against the two carcinoma cell lines with IC
50
values below 75 µM. IC
50
values below 10 µM were obtained for
4, 6
and
7
on SPC212 cells.
Conclusion
Based on the obtained results,
Ptycholobium contortum
turns to be a rich source of phenolic metabolites among them some bearing prenyl moieties. This study reports for the first time the isolation of pyrone derivatives
3
and
4
from
Ptycholobium
genus. The cytotoxicity observed for the isolate is also reported for the first time and shows that
4, 6
and
7
could be chemically explored in order to develop a hit candidate against lung cancer.
Graphical abstract
Two new pterocarpans and a new pyrone derivative with cytotoxic activities from ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone. |
| doi_str_mv | 10.1186/s13065-016-0204-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5050614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1879195111</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-3cf35467df9bbff75010e14c874ae30ef41a488173c126eb670105bc4903736a3</originalsourceid><addsrcrecordid>eNp1ks9u1DAQxiMEoqXwAFyQJS7bQxZPHDtZDpVo1QLSUhAqEjfLcSa7rhJ7sZ3981y8YF1tqRYkTjOa-c03M9KXZa-BTgFq8S4Ao4LnFEROC1rm2yfZMVS8yIGzn08P8qPsRQi3lPIaRPU8OypqBkKU7Dj7fbNxxOKGrCJ6p5VfKRuIsi1R-_LOO4ukRW_WKpo1ko2JS6J30UW3NZoonaomGgyk824g3-JOL13vGjMORDsbnY8pm1xPL6fnfnpKzv04DCZGMpnjYhyMdUHh6XvicW0CtuT6y3eiQjALO6CNxHVkGG079qhIn5ala15mzzrVB3z1EE-yH1eXNxef8vnXj58vPsxzXVY05kx3jJeiartZ03RdxSlQhFLXVamQUexKUGVdQ8U0FAIbUSWAN7qcUVYxodhJdrbXXY3NgK1O53jVy5U3g_I76ZSRf3esWcqFW0tOORVQJoHJg4B3v0YMUQ4maOx7ZdGNQUJdzWDGASChb_9Bb93obXovUYIXJfBCJAr2lPYuBI_d4zFA5b0l5N4SMllC3ltCbtPMm8MvHif-eCABxR4IqWUX6A9W_1f1DvYaxc0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1865241526</pqid></control><display><type>article</type><title>Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone</title><source>DOAJ Directory of Open Access Journals</source><source>SpringerNature Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>Access via BioMed Central</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Ngnintedo, Dominique ; Fotso, Ghislain W. ; Kuete, Victor ; Nana, Frederic ; Sandjo, Louis P. ; Karaosmanoğlu, Oğuzhan ; Sivas, Hülya ; Keumedjio, Felix ; Kirsch, Gilbert ; Ngadjui, Bonaventure T. ; Andrae-Marobela, Kerstin</creator><creatorcontrib>Ngnintedo, Dominique ; Fotso, Ghislain W. ; Kuete, Victor ; Nana, Frederic ; Sandjo, Louis P. ; Karaosmanoğlu, Oğuzhan ; Sivas, Hülya ; Keumedjio, Felix ; Kirsch, Gilbert ; Ngadjui, Bonaventure T. ; Andrae-Marobela, Kerstin</creatorcontrib><description>Background
Ptycholobium
is a genus related to
Tephrosia
which comprises only three species. Compared to
Tephrosia
, which has been phytochemically and pharmacologically studied,
Ptycholobium
species have only few or no reports on their chemical constituents. Moreover, no studies on the cytotoxic activities of its secondary metabolites have been previously documented.
Results
From the non polar fractions of the roots bark of
Ptycholobium contortum
(syn
Tephrosia contorta
), two new pterocarpans: seputhecarpan C
1
and seputhecarpan D
2
and a new pyrone derivative, ptycholopyrone A
3
were isolated. Alongside, five known compounds identified as 3-α,α-dimethylallyl-4-methoxy-6-styryl-α-pyrone or mundulea lactone
4
, glyasperin F
5
, seputhecarpan A
6
, seputheisoflavone
7
and 5-
O
-methyl-myo-inositol or sequoyitol
8
were also obtained. Their structures were established by the mean means of spectroscopic data in conjunction to those reported in literature. The NMR assignment of the major compound mundulea lactone
4
is revised in this paper. In addition, the cytotoxicity of the isolated metabolites was evaluated on two lung cancer cell lines A549 and SPC212.
8
was not active while compounds
1, 2, 4–7
displayed antiproliferative effects against the two carcinoma cell lines with IC
50
values below 75 µM. IC
50
values below 10 µM were obtained for
4, 6
and
7
on SPC212 cells.
Conclusion
Based on the obtained results,
Ptycholobium contortum
turns to be a rich source of phenolic metabolites among them some bearing prenyl moieties. This study reports for the first time the isolation of pyrone derivatives
3
and
4
from
Ptycholobium
genus. The cytotoxicity observed for the isolate is also reported for the first time and shows that
4, 6
and
7
could be chemically explored in order to develop a hit candidate against lung cancer.
Graphical abstract
Two new pterocarpans and a new pyrone derivative with cytotoxic activities from ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone.</description><identifier>ISSN: 1752-153X</identifier><identifier>EISSN: 1752-153X</identifier><identifier>EISSN: 2661-801X</identifier><identifier>DOI: 10.1186/s13065-016-0204-x</identifier><identifier>PMID: 28316643</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Cytotoxicity ; Metabolites ; Organic and Medicinal Chemistry ; Phytochemicals ; Research Article</subject><ispartof>BMC chemistry, 2016-10, Vol.10 (1), p.58-58, Article 58</ispartof><rights>The Author(s) 2016</rights><rights>Chemistry Central Journal is a copyright of Springer, 2016.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-3cf35467df9bbff75010e14c874ae30ef41a488173c126eb670105bc4903736a3</citedby><cites>FETCH-LOGICAL-c470t-3cf35467df9bbff75010e14c874ae30ef41a488173c126eb670105bc4903736a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050614/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050614/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28316643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ngnintedo, Dominique</creatorcontrib><creatorcontrib>Fotso, Ghislain W.</creatorcontrib><creatorcontrib>Kuete, Victor</creatorcontrib><creatorcontrib>Nana, Frederic</creatorcontrib><creatorcontrib>Sandjo, Louis P.</creatorcontrib><creatorcontrib>Karaosmanoğlu, Oğuzhan</creatorcontrib><creatorcontrib>Sivas, Hülya</creatorcontrib><creatorcontrib>Keumedjio, Felix</creatorcontrib><creatorcontrib>Kirsch, Gilbert</creatorcontrib><creatorcontrib>Ngadjui, Bonaventure T.</creatorcontrib><creatorcontrib>Andrae-Marobela, Kerstin</creatorcontrib><title>Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone</title><title>BMC chemistry</title><addtitle>Chemistry Central Journal</addtitle><addtitle>Chem Cent J</addtitle><description>Background
Ptycholobium
is a genus related to
Tephrosia
which comprises only three species. Compared to
Tephrosia
, which has been phytochemically and pharmacologically studied,
Ptycholobium
species have only few or no reports on their chemical constituents. Moreover, no studies on the cytotoxic activities of its secondary metabolites have been previously documented.
Results
From the non polar fractions of the roots bark of
Ptycholobium contortum
(syn
Tephrosia contorta
), two new pterocarpans: seputhecarpan C
1
and seputhecarpan D
2
and a new pyrone derivative, ptycholopyrone A
3
were isolated. Alongside, five known compounds identified as 3-α,α-dimethylallyl-4-methoxy-6-styryl-α-pyrone or mundulea lactone
4
, glyasperin F
5
, seputhecarpan A
6
, seputheisoflavone
7
and 5-
O
-methyl-myo-inositol or sequoyitol
8
were also obtained. Their structures were established by the mean means of spectroscopic data in conjunction to those reported in literature. The NMR assignment of the major compound mundulea lactone
4
is revised in this paper. In addition, the cytotoxicity of the isolated metabolites was evaluated on two lung cancer cell lines A549 and SPC212.
8
was not active while compounds
1, 2, 4–7
displayed antiproliferative effects against the two carcinoma cell lines with IC
50
values below 75 µM. IC
50
values below 10 µM were obtained for
4, 6
and
7
on SPC212 cells.
Conclusion
Based on the obtained results,
Ptycholobium contortum
turns to be a rich source of phenolic metabolites among them some bearing prenyl moieties. This study reports for the first time the isolation of pyrone derivatives
3
and
4
from
Ptycholobium
genus. The cytotoxicity observed for the isolate is also reported for the first time and shows that
4, 6
and
7
could be chemically explored in order to develop a hit candidate against lung cancer.
Graphical abstract
Two new pterocarpans and a new pyrone derivative with cytotoxic activities from ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone.</description><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Cytotoxicity</subject><subject>Metabolites</subject><subject>Organic and Medicinal Chemistry</subject><subject>Phytochemicals</subject><subject>Research Article</subject><issn>1752-153X</issn><issn>1752-153X</issn><issn>2661-801X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1ks9u1DAQxiMEoqXwAFyQJS7bQxZPHDtZDpVo1QLSUhAqEjfLcSa7rhJ7sZ3981y8YF1tqRYkTjOa-c03M9KXZa-BTgFq8S4Ao4LnFEROC1rm2yfZMVS8yIGzn08P8qPsRQi3lPIaRPU8OypqBkKU7Dj7fbNxxOKGrCJ6p5VfKRuIsi1R-_LOO4ukRW_WKpo1ko2JS6J30UW3NZoonaomGgyk824g3-JOL13vGjMORDsbnY8pm1xPL6fnfnpKzv04DCZGMpnjYhyMdUHh6XvicW0CtuT6y3eiQjALO6CNxHVkGG079qhIn5ala15mzzrVB3z1EE-yH1eXNxef8vnXj58vPsxzXVY05kx3jJeiartZ03RdxSlQhFLXVamQUexKUGVdQ8U0FAIbUSWAN7qcUVYxodhJdrbXXY3NgK1O53jVy5U3g_I76ZSRf3esWcqFW0tOORVQJoHJg4B3v0YMUQ4maOx7ZdGNQUJdzWDGASChb_9Bb93obXovUYIXJfBCJAr2lPYuBI_d4zFA5b0l5N4SMllC3ltCbtPMm8MvHif-eCABxR4IqWUX6A9W_1f1DvYaxc0</recordid><startdate>20161005</startdate><enddate>20161005</enddate><creator>Ngnintedo, Dominique</creator><creator>Fotso, Ghislain W.</creator><creator>Kuete, Victor</creator><creator>Nana, Frederic</creator><creator>Sandjo, Louis P.</creator><creator>Karaosmanoğlu, Oğuzhan</creator><creator>Sivas, Hülya</creator><creator>Keumedjio, Felix</creator><creator>Kirsch, Gilbert</creator><creator>Ngadjui, Bonaventure T.</creator><creator>Andrae-Marobela, Kerstin</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SR</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>K9.</scope><scope>KB.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161005</creationdate><title>Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone</title><author>Ngnintedo, Dominique ; Fotso, Ghislain W. ; Kuete, Victor ; Nana, Frederic ; Sandjo, Louis P. ; Karaosmanoğlu, Oğuzhan ; Sivas, Hülya ; Keumedjio, Felix ; Kirsch, Gilbert ; Ngadjui, Bonaventure T. ; Andrae-Marobela, Kerstin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-3cf35467df9bbff75010e14c874ae30ef41a488173c126eb670105bc4903736a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Cytotoxicity</topic><topic>Metabolites</topic><topic>Organic and Medicinal Chemistry</topic><topic>Phytochemicals</topic><topic>Research Article</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ngnintedo, Dominique</creatorcontrib><creatorcontrib>Fotso, Ghislain W.</creatorcontrib><creatorcontrib>Kuete, Victor</creatorcontrib><creatorcontrib>Nana, Frederic</creatorcontrib><creatorcontrib>Sandjo, Louis P.</creatorcontrib><creatorcontrib>Karaosmanoğlu, Oğuzhan</creatorcontrib><creatorcontrib>Sivas, Hülya</creatorcontrib><creatorcontrib>Keumedjio, Felix</creatorcontrib><creatorcontrib>Kirsch, Gilbert</creatorcontrib><creatorcontrib>Ngadjui, Bonaventure T.</creatorcontrib><creatorcontrib>Andrae-Marobela, Kerstin</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Engineered Materials Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ngnintedo, Dominique</au><au>Fotso, Ghislain W.</au><au>Kuete, Victor</au><au>Nana, Frederic</au><au>Sandjo, Louis P.</au><au>Karaosmanoğlu, Oğuzhan</au><au>Sivas, Hülya</au><au>Keumedjio, Felix</au><au>Kirsch, Gilbert</au><au>Ngadjui, Bonaventure T.</au><au>Andrae-Marobela, Kerstin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone</atitle><jtitle>BMC chemistry</jtitle><stitle>Chemistry Central Journal</stitle><addtitle>Chem Cent J</addtitle><date>2016-10-05</date><risdate>2016</risdate><volume>10</volume><issue>1</issue><spage>58</spage><epage>58</epage><pages>58-58</pages><artnum>58</artnum><issn>1752-153X</issn><eissn>1752-153X</eissn><eissn>2661-801X</eissn><abstract>Background
Ptycholobium
is a genus related to
Tephrosia
which comprises only three species. Compared to
Tephrosia
, which has been phytochemically and pharmacologically studied,
Ptycholobium
species have only few or no reports on their chemical constituents. Moreover, no studies on the cytotoxic activities of its secondary metabolites have been previously documented.
Results
From the non polar fractions of the roots bark of
Ptycholobium contortum
(syn
Tephrosia contorta
), two new pterocarpans: seputhecarpan C
1
and seputhecarpan D
2
and a new pyrone derivative, ptycholopyrone A
3
were isolated. Alongside, five known compounds identified as 3-α,α-dimethylallyl-4-methoxy-6-styryl-α-pyrone or mundulea lactone
4
, glyasperin F
5
, seputhecarpan A
6
, seputheisoflavone
7
and 5-
O
-methyl-myo-inositol or sequoyitol
8
were also obtained. Their structures were established by the mean means of spectroscopic data in conjunction to those reported in literature. The NMR assignment of the major compound mundulea lactone
4
is revised in this paper. In addition, the cytotoxicity of the isolated metabolites was evaluated on two lung cancer cell lines A549 and SPC212.
8
was not active while compounds
1, 2, 4–7
displayed antiproliferative effects against the two carcinoma cell lines with IC
50
values below 75 µM. IC
50
values below 10 µM were obtained for
4, 6
and
7
on SPC212 cells.
Conclusion
Based on the obtained results,
Ptycholobium contortum
turns to be a rich source of phenolic metabolites among them some bearing prenyl moieties. This study reports for the first time the isolation of pyrone derivatives
3
and
4
from
Ptycholobium
genus. The cytotoxicity observed for the isolate is also reported for the first time and shows that
4, 6
and
7
could be chemically explored in order to develop a hit candidate against lung cancer.
Graphical abstract
Two new pterocarpans and a new pyrone derivative with cytotoxic activities from ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28316643</pmid><doi>10.1186/s13065-016-0204-x</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1752-153X |
| ispartof | BMC chemistry, 2016-10, Vol.10 (1), p.58-58, Article 58 |
| issn | 1752-153X 1752-153X 2661-801X |
| language | eng |
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| source | DOAJ Directory of Open Access Journals; SpringerNature Journals; PubMed Central Open Access; Springer Nature OA Free Journals; Access via BioMed Central; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Chemistry Chemistry and Materials Science Chemistry/Food Science Cytotoxicity Metabolites Organic and Medicinal Chemistry Phytochemicals Research Article |
| title | Two new pterocarpans and a new pyrone derivative with cytotoxic activities from Ptycholobium contortum (N.E.Br.) Brummitt (Leguminosae): revised NMR assignment of mundulea lactone |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T23%3A33%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Two%20new%20pterocarpans%20and%20a%20new%20pyrone%20derivative%20with%20cytotoxic%20activities%20from%20Ptycholobium%20contortum%20(N.E.Br.)%20Brummitt%20(Leguminosae):%20revised%20NMR%20assignment%20of%20mundulea%20lactone&rft.jtitle=BMC%20chemistry&rft.au=Ngnintedo,%20Dominique&rft.date=2016-10-05&rft.volume=10&rft.issue=1&rft.spage=58&rft.epage=58&rft.pages=58-58&rft.artnum=58&rft.issn=1752-153X&rft.eissn=1752-153X&rft_id=info:doi/10.1186/s13065-016-0204-x&rft_dat=%3Cproquest_pubme%3E1879195111%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1865241526&rft_id=info:pmid/28316643&rfr_iscdi=true |