Neuregulin-Dependent Regulation of Fast-Spiking Interneuron Excitability Controls the Timing of the Critical Period

Maturation of excitatory drive onto fast-spiking interneurons (FS INs) in the visual cortex has been implicated in the control of the timing of the critical period for ocular dominance plasticity. However, the mechanisms that regulate the strength of these synapses over cortical development are not...

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Veröffentlicht in:	The Journal of neuroscience 2016-10, Vol.36 (40), p.10285-10295
Hauptverfasser:	Gu, Yu, Tran, Trinh, Murase, Sachiko, Borrell, Andrew, Kirkwood, Alfredo, Quinlan, Elizabeth M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amblyopia - physiopathology Animals Critical Period (Psychology) Dominance, Ocular - physiology Female Interneurons - physiology Male Mice Mice, Inbred C57BL Mice, Knockout Neuregulin-1 - antagonists & inhibitors Neuregulin-1 - genetics Neuregulin-1 - physiology Neuronal Plasticity - physiology Receptor, ErbB-4 - antagonists & inhibitors Receptor, ErbB-4 - genetics Receptor, ErbB-4 - physiology Recovery of Function - genetics Synapses - physiology Vision, Monocular - physiology Visual Cortex - cytology Visual Cortex - physiology
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