Integrin-α10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma

Myxofibrosarcoma is a common mesenchymal malignancy with complex genomics and heterogeneous clinical outcomes. Through gene-expression profiling of 64 primary high-grade myxofibrosarcomas, we defined an expression signature associated with clinical outcome. The gene most significantly associated wit...

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Veröffentlicht in:	Cancer discovery 2016-10, Vol.6 (10), p.1148-1165
Hauptverfasser:	Okada, Tomoyo, Lee, Ann Y, Qin, Li-Xuan, Agaram, Narasimhan, Mimae, Takahiro, Shen, Yawei, O'Connor, Rachael, López-Lago, Miguel A, Craig, Amanda, Miller, Martin L, Agius, Phaedra, Molinelli, Evan, Socci, Nicholas D, Crago, Aimee M, Shima, Fumi, Sander, Chris, Singer, Samuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - genetics Cell Line, Tumor Fibrosarcoma - drug therapy Fibrosarcoma - genetics Fibrosarcoma - metabolism Fibrosarcoma - pathology Gene Expression Profiling Gene Expression Regulation, Neoplastic Guanine Nucleotide Exchange Factors - genetics Humans Integrin alpha Chains - genetics Integrin alpha Chains - metabolism Mice Molecular Targeted Therapy Neoplasm Grading Neoplasm Transplantation Protein Serine-Threonine Kinases - genetics Proto-Oncogene Proteins c-akt - genetics rac GTP-Binding Proteins - genetics Rapamycin-Insensitive Companion of mTOR Protein Signal Transduction TOR Serine-Threonine Kinases - genetics Up-Regulation
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