Vascular Targeted Radioimmunotherapy for the Treatment of Glioblastoma

Glioblastoma is characterized by an aggressive and aberrant vascular network that promotes tumor progression and hinders effective treatment; the median survival is 16 mo despite standard-of-care therapies. There is a need to improve therapeutic options for this disease. We hypothesized that antibod...

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Veröffentlicht in:	Journal of Nuclear Medicine 2016-10, Vol.57 (10), p.1576-1582
Hauptverfasser:	Behling, Katja, Maguire, William F, López Puebla, José Carlos, Sprinkle, Shanna R, Ruggiero, Alessandro, O'Donoghue, Joseph, Gutin, Philip H, Scheinberg, David A, McDevitt, Michael R
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinium Alpha Particles - therapeutic use Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - therapeutic use Basic Science Investigations Blood Vessels - metabolism Blood Vessels - radiation effects Brain cancer Brain Neoplasms - blood supply Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - radiotherapy Cell Line, Tumor Glioblastoma - blood supply Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma - radiotherapy Histology Humans Immunotherapy Mice Neoplasm Grading Nuclear medicine Pharmacology Radiochemistry Radioimmunotherapy - methods Radiotherapy Dosage Tumors
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