Membrane Interaction of the Factor VIIIa Discoidin Domains in Atomistic Detail

A recently developed membrane-mimetic model was applied to study membrane interaction and binding of the two anchoring C2-like discoidin domains of human coagulation factor VIIIa (FVIIIa), the C1 and C2 domains. Both individual domains, FVIII C1 and FVIII C2, were observed to bind the phospholipid m...

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Veröffentlicht in:	Biochemistry (Easton) 2015-10, Vol.54 (39), p.6123-6131
Hauptverfasser:	Madsen, Jesper J, Ohkubo, Y. Zenmei, Peters, Günther H, Faber, Johan H, Tajkhorshid, Emad, Olsen, Ole H
Format:	Artikel
Sprache:	eng
Schlagworte:	antibodies coagulation epitopes Epitopes - chemistry Epitopes - genetics Epitopes - metabolism Factor VIII - chemistry Factor VIII - genetics Factor VIII - metabolism Hemophilia A - genetics Hemophilia A - metabolism Humans Membranes, Artificial missense mutation Mutation, Missense phospholipids Phospholipids - chemistry Phospholipids - genetics Phospholipids - metabolism Protein Structure, Secondary Protein Structure, Tertiary
Online-Zugang:	Volltext
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