Plant-like biosynthesis of isoquinoline alkaloids in Aspergillus fumigatus

Analysis of orphan nonribosomal peptide synthetase–like gene clusters from Aspergillus fumigatus identified a gene cluster responsible for the biosynthesis of fumisoquin isoquinoline alkaloids by amino acid condensation and subsequent tailoring steps reminiscent of plant biosynthetic pathways. Natur...

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Veröffentlicht in:	Nature chemical biology 2016-06, Vol.12 (6), p.419-424
Hauptverfasser:	Baccile, Joshua A, Spraker, Joseph E, Le, Henry H, Brandenburger, Eileen, Gomez, Christian, Bok, Jin Woo, Macheleidt, Juliane, Brakhage, Axel A, Hoffmeister, Dirk, Keller, Nancy P, Schroeder, Frank C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/92/349 631/92/60 631/92/607 639/638/11/872 82/16 82/83 Alkaloids - biosynthesis Alkaloids - chemistry Amino acids Aspergillus fumigatus Aspergillus fumigatus - genetics Aspergillus fumigatus - metabolism Biochemical Engineering Biochemistry Bioorganic Chemistry Biosynthesis Biosynthetic Pathways - genetics Carbon Cell Biology Chemistry Chemistry/Food Science Enzymes Isoquinolines - chemistry Isoquinolines - metabolism Metabolomics Molecular Structure Multigene Family Natural products Pathogens Plants - genetics Plants - metabolism
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