Cancer in Parkinson’s disease
Abstract INTRODUCTION We examined the prevalence of cancer in patients with Parkinson’s disease (PD) and controls evaluated at the Mayo Clinic in Jacksonville, Florida, between 2003 and 2014. METHODS We retrospectively collected information regarding cancer diagnoses and diagnosis of PD from 971 unr...
Gespeichert in:
| Veröffentlicht in: | Parkinsonism & related disorders 2016-10, Vol.31, p.28-33 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 33 |
|---|---|
| container_issue | |
| container_start_page | 28 |
| container_title | Parkinsonism & related disorders |
| container_volume | 31 |
| creator | Tacik, Pawel Curry, Sadie Fujioka, Shinsuke Strongosky, Audrey Uitti, Ryan J van Gerpen, Jay A Diehl, Nancy N Heckman, Michael G Wszolek, Zbigniew K |
| description | Abstract INTRODUCTION We examined the prevalence of cancer in patients with Parkinson’s disease (PD) and controls evaluated at the Mayo Clinic in Jacksonville, Florida, between 2003 and 2014. METHODS We retrospectively collected information regarding cancer diagnoses and diagnosis of PD from 971 unrelated PD patients and 478 controls, and all were white. For PD patients, we examined cancers diagnosed before and after PD diagnosis separately in addition to considering all cancer diagnoses. RESULTS Twenty different cancers were identified. In PD patients, the most common types of cancer were skin cancer (17.3% overall; 10.6% before PD), followed by nonmelanoma skin cancer (16.0% overall; 9.7% before PD), prostate cancer in men (12.8% overall; 9.2% before PD), breast cancer in women (10.6% overall; 6.3% before PD), and melanoma (2.4% overall; 1.1% before PD). Compared to controls, a significantly lower frequency of nonmelanoma skin cancer (odds ratio [OR]: 0.62, P = 0.0024) and any skin cancer (OR: 0.57, P = 0.0002) was observed in PD patients. These differences were greater when considering only cases with cancers that occurred before PD diagnosis (OR: 0.49, P |
| doi_str_mv | 10.1016/j.parkreldis.2016.06.014 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5048511</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S1353802016302346</els_id><sourcerecordid>1826715648</sourcerecordid><originalsourceid>FETCH-LOGICAL-c534t-d8b1fb2bc08787883b2fecaa1ca995eee6ffd5b8931a928df45e8875b70be7053</originalsourceid><addsrcrecordid>eNqNkc9OGzEQxi0EKpT2FWiOXDadsddr54LURv0nIVEJeh55vbPgsPGmdoLEra_R1-uT1FEo0J4qj2TL_uYb6_cJMUGYImDzdjFduXSbeOhCnspyM4VSWO-JI7RGVRpls1_OSqvKgoRD8TLnBQAYDeqFOJRGGSlrPBJv5i56TpMQJ1-LZYh5jL9-_MyT4swu8ytx0Lsh8-uH_Vh8-_jhav65Or_49GX-7rzyWtXrqrMt9q1sPVhTllWt7Nk7h97NZpqZm77vdGtnCt1M2q6vNVtrdGugZQNaHYuzne9q0y658xzXyQ20SmHp0j2NLtDfLzHc0PV4RxpqqxGLwemDQRq_bzivaRmy52FwkcdNJrSyMaib2hap3Ul9GnNO3D-OQaAtX1rQE1_a8iUohXVpPXn-zcfGP0CL4P1OwAXWXeBE2QcuiLuQ2K-pG8P_TDn7x8QPIQbvhlu-57wYNymWMAgpSwK63Oa8jRkbBVLVjfoNf46naA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1826715648</pqid></control><display><type>article</type><title>Cancer in Parkinson’s disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Tacik, Pawel ; Curry, Sadie ; Fujioka, Shinsuke ; Strongosky, Audrey ; Uitti, Ryan J ; van Gerpen, Jay A ; Diehl, Nancy N ; Heckman, Michael G ; Wszolek, Zbigniew K</creator><creatorcontrib>Tacik, Pawel ; Curry, Sadie ; Fujioka, Shinsuke ; Strongosky, Audrey ; Uitti, Ryan J ; van Gerpen, Jay A ; Diehl, Nancy N ; Heckman, Michael G ; Wszolek, Zbigniew K</creatorcontrib><description>Abstract INTRODUCTION We examined the prevalence of cancer in patients with Parkinson’s disease (PD) and controls evaluated at the Mayo Clinic in Jacksonville, Florida, between 2003 and 2014. METHODS We retrospectively collected information regarding cancer diagnoses and diagnosis of PD from 971 unrelated PD patients and 478 controls, and all were white. For PD patients, we examined cancers diagnosed before and after PD diagnosis separately in addition to considering all cancer diagnoses. RESULTS Twenty different cancers were identified. In PD patients, the most common types of cancer were skin cancer (17.3% overall; 10.6% before PD), followed by nonmelanoma skin cancer (16.0% overall; 9.7% before PD), prostate cancer in men (12.8% overall; 9.2% before PD), breast cancer in women (10.6% overall; 6.3% before PD), and melanoma (2.4% overall; 1.1% before PD). Compared to controls, a significantly lower frequency of nonmelanoma skin cancer (odds ratio [OR]: 0.62, P = 0.0024) and any skin cancer (OR: 0.57, P = 0.0002) was observed in PD patients. These differences were greater when considering only cases with cancers that occurred before PD diagnosis (OR: 0.49, P < 0.0001; OR: 0.45, P < 0.0001, respectively), and there was a lower frequency of melanoma and any cancer preceding PD diagnosis compared to controls (OR: 0.31, P = 0.003; OR: 0.36, P < 0.0001). There was no evidence of a frequency difference for any other cancer. CONCLUSIONS PD patients had a lower frequency of skin cancers or any cancer prior to PD diagnosis compared to controls, suggesting that cancer may have a protective effect on PD risk.</description><identifier>ISSN: 1353-8020</identifier><identifier>EISSN: 1873-5126</identifier><identifier>DOI: 10.1016/j.parkreldis.2016.06.014</identifier><identifier>PMID: 27372241</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Age Distribution ; Age Factors ; Aged ; Aged, 80 and over ; Basal ganglia ; Cancer ; Female ; Humans ; Male ; Melanoma ; Middle Aged ; Neoplasms - classification ; Neoplasms - epidemiology ; Neurology ; Parkinson Disease - epidemiology ; Parkinsonism ; Parkinson’s disease ; Primary brain tumor ; Retrospective Studies ; Young Adult</subject><ispartof>Parkinsonism & related disorders, 2016-10, Vol.31, p.28-33</ispartof><rights>Elsevier Ltd</rights><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c534t-d8b1fb2bc08787883b2fecaa1ca995eee6ffd5b8931a928df45e8875b70be7053</citedby><cites>FETCH-LOGICAL-c534t-d8b1fb2bc08787883b2fecaa1ca995eee6ffd5b8931a928df45e8875b70be7053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1353802016302346$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27372241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tacik, Pawel</creatorcontrib><creatorcontrib>Curry, Sadie</creatorcontrib><creatorcontrib>Fujioka, Shinsuke</creatorcontrib><creatorcontrib>Strongosky, Audrey</creatorcontrib><creatorcontrib>Uitti, Ryan J</creatorcontrib><creatorcontrib>van Gerpen, Jay A</creatorcontrib><creatorcontrib>Diehl, Nancy N</creatorcontrib><creatorcontrib>Heckman, Michael G</creatorcontrib><creatorcontrib>Wszolek, Zbigniew K</creatorcontrib><title>Cancer in Parkinson’s disease</title><title>Parkinsonism & related disorders</title><addtitle>Parkinsonism Relat Disord</addtitle><description>Abstract INTRODUCTION We examined the prevalence of cancer in patients with Parkinson’s disease (PD) and controls evaluated at the Mayo Clinic in Jacksonville, Florida, between 2003 and 2014. METHODS We retrospectively collected information regarding cancer diagnoses and diagnosis of PD from 971 unrelated PD patients and 478 controls, and all were white. For PD patients, we examined cancers diagnosed before and after PD diagnosis separately in addition to considering all cancer diagnoses. RESULTS Twenty different cancers were identified. In PD patients, the most common types of cancer were skin cancer (17.3% overall; 10.6% before PD), followed by nonmelanoma skin cancer (16.0% overall; 9.7% before PD), prostate cancer in men (12.8% overall; 9.2% before PD), breast cancer in women (10.6% overall; 6.3% before PD), and melanoma (2.4% overall; 1.1% before PD). Compared to controls, a significantly lower frequency of nonmelanoma skin cancer (odds ratio [OR]: 0.62, P = 0.0024) and any skin cancer (OR: 0.57, P = 0.0002) was observed in PD patients. These differences were greater when considering only cases with cancers that occurred before PD diagnosis (OR: 0.49, P < 0.0001; OR: 0.45, P < 0.0001, respectively), and there was a lower frequency of melanoma and any cancer preceding PD diagnosis compared to controls (OR: 0.31, P = 0.003; OR: 0.36, P < 0.0001). There was no evidence of a frequency difference for any other cancer. CONCLUSIONS PD patients had a lower frequency of skin cancers or any cancer prior to PD diagnosis compared to controls, suggesting that cancer may have a protective effect on PD risk.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Basal ganglia</subject><subject>Cancer</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Melanoma</subject><subject>Middle Aged</subject><subject>Neoplasms - classification</subject><subject>Neoplasms - epidemiology</subject><subject>Neurology</subject><subject>Parkinson Disease - epidemiology</subject><subject>Parkinsonism</subject><subject>Parkinson’s disease</subject><subject>Primary brain tumor</subject><subject>Retrospective Studies</subject><subject>Young Adult</subject><issn>1353-8020</issn><issn>1873-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9OGzEQxi0EKpT2FWiOXDadsddr54LURv0nIVEJeh55vbPgsPGmdoLEra_R1-uT1FEo0J4qj2TL_uYb6_cJMUGYImDzdjFduXSbeOhCnspyM4VSWO-JI7RGVRpls1_OSqvKgoRD8TLnBQAYDeqFOJRGGSlrPBJv5i56TpMQJ1-LZYh5jL9-_MyT4swu8ytx0Lsh8-uH_Vh8-_jhav65Or_49GX-7rzyWtXrqrMt9q1sPVhTllWt7Nk7h97NZpqZm77vdGtnCt1M2q6vNVtrdGugZQNaHYuzne9q0y658xzXyQ20SmHp0j2NLtDfLzHc0PV4RxpqqxGLwemDQRq_bzivaRmy52FwkcdNJrSyMaib2hap3Ul9GnNO3D-OQaAtX1rQE1_a8iUohXVpPXn-zcfGP0CL4P1OwAXWXeBE2QcuiLuQ2K-pG8P_TDn7x8QPIQbvhlu-57wYNymWMAgpSwK63Oa8jRkbBVLVjfoNf46naA</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Tacik, Pawel</creator><creator>Curry, Sadie</creator><creator>Fujioka, Shinsuke</creator><creator>Strongosky, Audrey</creator><creator>Uitti, Ryan J</creator><creator>van Gerpen, Jay A</creator><creator>Diehl, Nancy N</creator><creator>Heckman, Michael G</creator><creator>Wszolek, Zbigniew K</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20161001</creationdate><title>Cancer in Parkinson’s disease</title><author>Tacik, Pawel ; Curry, Sadie ; Fujioka, Shinsuke ; Strongosky, Audrey ; Uitti, Ryan J ; van Gerpen, Jay A ; Diehl, Nancy N ; Heckman, Michael G ; Wszolek, Zbigniew K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c534t-d8b1fb2bc08787883b2fecaa1ca995eee6ffd5b8931a928df45e8875b70be7053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Basal ganglia</topic><topic>Cancer</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Melanoma</topic><topic>Middle Aged</topic><topic>Neoplasms - classification</topic><topic>Neoplasms - epidemiology</topic><topic>Neurology</topic><topic>Parkinson Disease - epidemiology</topic><topic>Parkinsonism</topic><topic>Parkinson’s disease</topic><topic>Primary brain tumor</topic><topic>Retrospective Studies</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tacik, Pawel</creatorcontrib><creatorcontrib>Curry, Sadie</creatorcontrib><creatorcontrib>Fujioka, Shinsuke</creatorcontrib><creatorcontrib>Strongosky, Audrey</creatorcontrib><creatorcontrib>Uitti, Ryan J</creatorcontrib><creatorcontrib>van Gerpen, Jay A</creatorcontrib><creatorcontrib>Diehl, Nancy N</creatorcontrib><creatorcontrib>Heckman, Michael G</creatorcontrib><creatorcontrib>Wszolek, Zbigniew K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Parkinsonism & related disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tacik, Pawel</au><au>Curry, Sadie</au><au>Fujioka, Shinsuke</au><au>Strongosky, Audrey</au><au>Uitti, Ryan J</au><au>van Gerpen, Jay A</au><au>Diehl, Nancy N</au><au>Heckman, Michael G</au><au>Wszolek, Zbigniew K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer in Parkinson’s disease</atitle><jtitle>Parkinsonism & related disorders</jtitle><addtitle>Parkinsonism Relat Disord</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>31</volume><spage>28</spage><epage>33</epage><pages>28-33</pages><issn>1353-8020</issn><eissn>1873-5126</eissn><abstract>Abstract INTRODUCTION We examined the prevalence of cancer in patients with Parkinson’s disease (PD) and controls evaluated at the Mayo Clinic in Jacksonville, Florida, between 2003 and 2014. METHODS We retrospectively collected information regarding cancer diagnoses and diagnosis of PD from 971 unrelated PD patients and 478 controls, and all were white. For PD patients, we examined cancers diagnosed before and after PD diagnosis separately in addition to considering all cancer diagnoses. RESULTS Twenty different cancers were identified. In PD patients, the most common types of cancer were skin cancer (17.3% overall; 10.6% before PD), followed by nonmelanoma skin cancer (16.0% overall; 9.7% before PD), prostate cancer in men (12.8% overall; 9.2% before PD), breast cancer in women (10.6% overall; 6.3% before PD), and melanoma (2.4% overall; 1.1% before PD). Compared to controls, a significantly lower frequency of nonmelanoma skin cancer (odds ratio [OR]: 0.62, P = 0.0024) and any skin cancer (OR: 0.57, P = 0.0002) was observed in PD patients. These differences were greater when considering only cases with cancers that occurred before PD diagnosis (OR: 0.49, P < 0.0001; OR: 0.45, P < 0.0001, respectively), and there was a lower frequency of melanoma and any cancer preceding PD diagnosis compared to controls (OR: 0.31, P = 0.003; OR: 0.36, P < 0.0001). There was no evidence of a frequency difference for any other cancer. CONCLUSIONS PD patients had a lower frequency of skin cancers or any cancer prior to PD diagnosis compared to controls, suggesting that cancer may have a protective effect on PD risk.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>27372241</pmid><doi>10.1016/j.parkreldis.2016.06.014</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1353-8020 |
| ispartof | Parkinsonism & related disorders, 2016-10, Vol.31, p.28-33 |
| issn | 1353-8020 1873-5126 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5048511 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Age Distribution Age Factors Aged Aged, 80 and over Basal ganglia Cancer Female Humans Male Melanoma Middle Aged Neoplasms - classification Neoplasms - epidemiology Neurology Parkinson Disease - epidemiology Parkinsonism Parkinson’s disease Primary brain tumor Retrospective Studies Young Adult |
| title | Cancer in Parkinson’s disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A34%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cancer%20in%20Parkinson%E2%80%99s%20disease&rft.jtitle=Parkinsonism%20&%20related%20disorders&rft.au=Tacik,%20Pawel&rft.date=2016-10-01&rft.volume=31&rft.spage=28&rft.epage=33&rft.pages=28-33&rft.issn=1353-8020&rft.eissn=1873-5126&rft_id=info:doi/10.1016/j.parkreldis.2016.06.014&rft_dat=%3Cproquest_pubme%3E1826715648%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1826715648&rft_id=info:pmid/27372241&rft_els_id=1_s2_0_S1353802016302346&rfr_iscdi=true |