CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice

Narcolepsy with cataplexy is a rare and severe sleep disorder caused by the destruction of orexinergic neurons in the lateral hypothalamus. The genetic and environmental factors associated with narcolepsy, together with serologic data, collectively point to an autoimmune origin. The current animal m...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-09, Vol.113 (39), p.10956-10961
Hauptverfasser:	Bernard-Valnet, Raphaël, Yshii, Lidia, Quériault, Clémence, Nguyen, Xuan-Hung, Arthaud, Sébastien, Rodrigues, Magda, Canivet, Astrid, Morel, Anne-Laure, Matthys, Arthur, Bauer, Jan, Pignolet, Béatrice, Dauvilliers, Yves, Peyron, Christelle, Liblau, Roland S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - metabolism Autoantigens - metabolism Biological Sciences CD8-Positive T-Lymphocytes - immunology Cell Communication Cytotoxicity, Immunologic Genotype & phenotype Glycoproteins Hemagglutinins - metabolism Human health and pathology Hypothalamus - metabolism Inflammation - pathology Life Sciences Lymphocytes Macrophages - metabolism Mice, Inbred C57BL Narcolepsy - immunology Narcolepsy - pathology Neurons Neurons - metabolism Neurons - pathology Orexins - metabolism Phenotype Sleep disorders T-Lymphocytes, Cytotoxic - metabolism Th1 Cells - metabolism
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