A validated metabolomic signature for colorectal cancer: exploration of the clinical value of metabolomics

Background: Timely diagnosis and classification of colorectal cancer (CRC) are hindered by unsatisfactory clinical assays. Our aim was to construct a blood-based biomarker series using a single assay, suitable for CRC detection, prognostication and staging. Methods: Serum metabolomic profiles of ade...

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Veröffentlicht in:	British journal of cancer 2016-09, Vol.115 (7), p.848-857
Hauptverfasser:	Farshidfar, Farshad, Weljie, Aalim M, Kopciuk, Karen A, Hilsden, Robert, McGregor, S Elizabeth, Buie, W Donald, MacLean, Anthony, Vogel, Hans J, Bathe, Oliver F
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/320 692/53/2422 692/699/67/1504/1885 692/699/67/1857 Adenocarcinoma - blood Adenocarcinoma - diagnosis Adenocarcinoma - genetics Adenocarcinoma - pathology Adenoma - blood Adenoma - diagnosis Adenoma - genetics Adenoma - pathology Aged Aged, 80 and over Biomarkers Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Cancer Research Case-Control Studies Chromatography Colonoscopy Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Discriminant analysis Disease Progression Drug Resistance Early Detection of Cancer Epidemiology Female Gene Expression Regulation, Neoplastic Health services Humans Least-Squares Analysis Male Mass spectrometry Medical research Medical screening Metabolites Metabolome Metabolomics Metastasis Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Neoplasm Staging Oncology Prognosis Prospective Studies ROC Curve Scientific imaging Sensitivity and Specificity Transcriptome Tumors
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