Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice

Sepsis-induced lymphopenia is a major cause of morbidities in intensive care units and in populations with chronic conditions such as renal failure, diabetes, HIV and alcohol abuse. Currently, other than supportive care and antibiotics, there are no treatments for this condition. We developed an in...

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Veröffentlicht in:	Scientific reports 2016-10, Vol.6 (1), p.34702-34702, Article 34702
Hauptverfasser:	Doerflinger, Marcel, Glab, Jason, Nedeva, Christina, Jose, Irvin, Lin, Ann, O’Reilly, Lorraine, Allison, Cody, Pellegrini, Marc, Hotchkiss, Richard S., Puthalakath, Hamsa
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 13/51 631/250 631/45/470/1981 64/60 692/699/255/1318 82 82/1 82/29 Abuse Alcohol abuse Animal models Antibiotics Apoptosis BIM protein Chaperones Chronic illnesses Diabetes mellitus Drug abuse Homeostasis Hospitals Humanities and Social Sciences Intensive care units Kidneys Lymphocytes Lymphopenia multidisciplinary Renal failure Rodents Science Sepsis Survival
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