Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study
The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study. We included 8452 participants (mean age 65...
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| Veröffentlicht in: | BMC medicine 2016-09, Vol.14 (1), p.150-150, Article 150 |
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| creator | Chaker, Layal Ligthart, Symen Korevaar, Tim I M Hofman, Albert Franco, Oscar H Peeters, Robin P Dehghan, Abbas |
| description | The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study.
We included 8452 participants (mean age 65 years) with thyroid function measurement, defined by thyroid-stimulating hormone (TSH) and free thyroxine (FT4), and longitudinal assessment of diabetes incidence. Cox-models were used to investigate the association of TSH and FT4 with diabetes and progression from prediabetes to diabetes. Multivariable models were adjusted for age, sex, high-density lipoprotein cholesterol, and glucose at baseline, amongst others.
During a mean follow-up of 7.9 years, 798 diabetes cases occurred. Higher TSH levels were associated with a higher diabetes risk (hazard ratio [HR] 1.13; 95 % confidence interval [CI], 1.08-1.18, per logTSH), even within the reference range of thyroid function (HR 1.24; 95 % CI, 1.06-1.45). Higher FT4 levels were associated with a lower diabetes risk amongst all participants (HR 0.96; 95 % CI, 0.93-0.99, per 1 pmol/L) and in participants within the reference range of thyroid function (HR 0.96; 95 % CI, 0.92-0.99). The risk of progression from prediabetes to diabetes was higher with low-normal thyroid function (HR 1.32; 95 % CI, 1.06-1.64 for TSH and HR 0.91; 95 % CI, 0.86-0.97 for FT4). Absolute risk of developing diabetes type 2 in participants with prediabetes decreased from 35 % to almost 15 % with higher FT4 levels within the normal range.
Low and low-normal thyroid function are risk factors for incident diabetes, especially in individuals with prediabetes. Future studies should investigate whether screening for and treatment of (subclinical) hypothyroidism is beneficial in subjects at risk of developing diabetes. |
| doi_str_mv | 10.1186/s12916-016-0693-4 |
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We included 8452 participants (mean age 65 years) with thyroid function measurement, defined by thyroid-stimulating hormone (TSH) and free thyroxine (FT4), and longitudinal assessment of diabetes incidence. Cox-models were used to investigate the association of TSH and FT4 with diabetes and progression from prediabetes to diabetes. Multivariable models were adjusted for age, sex, high-density lipoprotein cholesterol, and glucose at baseline, amongst others.
During a mean follow-up of 7.9 years, 798 diabetes cases occurred. Higher TSH levels were associated with a higher diabetes risk (hazard ratio [HR] 1.13; 95 % confidence interval [CI], 1.08-1.18, per logTSH), even within the reference range of thyroid function (HR 1.24; 95 % CI, 1.06-1.45). Higher FT4 levels were associated with a lower diabetes risk amongst all participants (HR 0.96; 95 % CI, 0.93-0.99, per 1 pmol/L) and in participants within the reference range of thyroid function (HR 0.96; 95 % CI, 0.92-0.99). The risk of progression from prediabetes to diabetes was higher with low-normal thyroid function (HR 1.32; 95 % CI, 1.06-1.64 for TSH and HR 0.91; 95 % CI, 0.86-0.97 for FT4). Absolute risk of developing diabetes type 2 in participants with prediabetes decreased from 35 % to almost 15 % with higher FT4 levels within the normal range.
Low and low-normal thyroid function are risk factors for incident diabetes, especially in individuals with prediabetes. Future studies should investigate whether screening for and treatment of (subclinical) hypothyroidism is beneficial in subjects at risk of developing diabetes.</description><identifier>ISSN: 1741-7015</identifier><identifier>EISSN: 1741-7015</identifier><identifier>DOI: 10.1186/s12916-016-0693-4</identifier><identifier>PMID: 27686165</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Blood pressure ; Body mass index ; Care and treatment ; Cholesterol ; Cohort analysis ; Complications and side effects ; Cross-sectional studies ; Diabetes ; Glucose ; Health aspects ; Hormone replacement therapy ; Hyperthyroidism ; Hypothyroidism ; Immunoassay ; Insulin resistance ; Metabolism ; Pharmacy ; Questionnaires ; Thyroid diseases ; Thyrotropin ; Type 2 diabetes</subject><ispartof>BMC medicine, 2016-09, Vol.14 (1), p.150-150, Article 150</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>The Author(s). 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-9ef07e6e195ae98ed6535a940ea8559ecac03561529d90b2ba9ebc5d0875d4933</citedby><cites>FETCH-LOGICAL-c591t-9ef07e6e195ae98ed6535a940ea8559ecac03561529d90b2ba9ebc5d0875d4933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043536/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5043536/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27686165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaker, Layal</creatorcontrib><creatorcontrib>Ligthart, Symen</creatorcontrib><creatorcontrib>Korevaar, Tim I M</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Franco, Oscar H</creatorcontrib><creatorcontrib>Peeters, Robin P</creatorcontrib><creatorcontrib>Dehghan, Abbas</creatorcontrib><title>Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study</title><title>BMC medicine</title><addtitle>BMC Med</addtitle><description>The association of thyroid function with risk of type 2 diabetes remains elusive. We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study.
We included 8452 participants (mean age 65 years) with thyroid function measurement, defined by thyroid-stimulating hormone (TSH) and free thyroxine (FT4), and longitudinal assessment of diabetes incidence. Cox-models were used to investigate the association of TSH and FT4 with diabetes and progression from prediabetes to diabetes. Multivariable models were adjusted for age, sex, high-density lipoprotein cholesterol, and glucose at baseline, amongst others.
During a mean follow-up of 7.9 years, 798 diabetes cases occurred. Higher TSH levels were associated with a higher diabetes risk (hazard ratio [HR] 1.13; 95 % confidence interval [CI], 1.08-1.18, per logTSH), even within the reference range of thyroid function (HR 1.24; 95 % CI, 1.06-1.45). Higher FT4 levels were associated with a lower diabetes risk amongst all participants (HR 0.96; 95 % CI, 0.93-0.99, per 1 pmol/L) and in participants within the reference range of thyroid function (HR 0.96; 95 % CI, 0.92-0.99). The risk of progression from prediabetes to diabetes was higher with low-normal thyroid function (HR 1.32; 95 % CI, 1.06-1.64 for TSH and HR 0.91; 95 % CI, 0.86-0.97 for FT4). Absolute risk of developing diabetes type 2 in participants with prediabetes decreased from 35 % to almost 15 % with higher FT4 levels within the normal range.
Low and low-normal thyroid function are risk factors for incident diabetes, especially in individuals with prediabetes. Future studies should investigate whether screening for and treatment of (subclinical) hypothyroidism is beneficial in subjects at risk of developing diabetes.</description><subject>Analysis</subject><subject>Blood pressure</subject><subject>Body mass index</subject><subject>Care and treatment</subject><subject>Cholesterol</subject><subject>Cohort analysis</subject><subject>Complications and side effects</subject><subject>Cross-sectional studies</subject><subject>Diabetes</subject><subject>Glucose</subject><subject>Health aspects</subject><subject>Hormone replacement therapy</subject><subject>Hyperthyroidism</subject><subject>Hypothyroidism</subject><subject>Immunoassay</subject><subject>Insulin resistance</subject><subject>Metabolism</subject><subject>Pharmacy</subject><subject>Questionnaires</subject><subject>Thyroid diseases</subject><subject>Thyrotropin</subject><subject>Type 2 diabetes</subject><issn>1741-7015</issn><issn>1741-7015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkk1r3DAQhkVpadK0P6CXIiiUXpxI1oetHgoh9CMQyCU99CRkaRwr9UquZAf231dm03Q3FDFISM_7DpoZhN5SckppK88yrRWVFVlDKlbxZ-iYNpxWDaHi-d75CL3K-Y6QWjQNf4mO6ka2kkpxjH7eDNsUvcP9EuzsY8AmOJx8_oVjj-ftBLjGzpsOZsifsMFTnJbRrGTVmQwOTynmCYr2HrCNQ0wzzvPitq_Ri96MGd487Cfox9cvNxffq6vrb5cX51eVFYrOlYKeNCCBKmFAteCkYMIoTsC0QiiwxhImJBW1cop0dWcUdFY40jbCccXYCfq8852WbgPOQpiTGfWU_MakrY7G68OX4Ad9G--1IJwJJovBxweDFH8vkGe98dnCOJoAccmatkxwKilbc71_gt7FJYXyvULVoial2OQfdWtG0D70seS1q6k-51LQAjYrdfofqiwHG29jgN6X-wPBhz3BAGachxzHZe1FPgTpDrSlNTlB_1gMSvQ6OHo3OJqsUQZH86J5t1_FR8XfSWF_AAr7vKY</recordid><startdate>20160930</startdate><enddate>20160930</enddate><creator>Chaker, Layal</creator><creator>Ligthart, Symen</creator><creator>Korevaar, Tim I M</creator><creator>Hofman, Albert</creator><creator>Franco, Oscar H</creator><creator>Peeters, Robin P</creator><creator>Dehghan, Abbas</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20160930</creationdate><title>Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study</title><author>Chaker, Layal ; 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We aimed to investigate the association of thyroid function with incident diabetes and progression from prediabetes to diabetes in a population-based prospective cohort study.
We included 8452 participants (mean age 65 years) with thyroid function measurement, defined by thyroid-stimulating hormone (TSH) and free thyroxine (FT4), and longitudinal assessment of diabetes incidence. Cox-models were used to investigate the association of TSH and FT4 with diabetes and progression from prediabetes to diabetes. Multivariable models were adjusted for age, sex, high-density lipoprotein cholesterol, and glucose at baseline, amongst others.
During a mean follow-up of 7.9 years, 798 diabetes cases occurred. Higher TSH levels were associated with a higher diabetes risk (hazard ratio [HR] 1.13; 95 % confidence interval [CI], 1.08-1.18, per logTSH), even within the reference range of thyroid function (HR 1.24; 95 % CI, 1.06-1.45). Higher FT4 levels were associated with a lower diabetes risk amongst all participants (HR 0.96; 95 % CI, 0.93-0.99, per 1 pmol/L) and in participants within the reference range of thyroid function (HR 0.96; 95 % CI, 0.92-0.99). The risk of progression from prediabetes to diabetes was higher with low-normal thyroid function (HR 1.32; 95 % CI, 1.06-1.64 for TSH and HR 0.91; 95 % CI, 0.86-0.97 for FT4). Absolute risk of developing diabetes type 2 in participants with prediabetes decreased from 35 % to almost 15 % with higher FT4 levels within the normal range.
Low and low-normal thyroid function are risk factors for incident diabetes, especially in individuals with prediabetes. Future studies should investigate whether screening for and treatment of (subclinical) hypothyroidism is beneficial in subjects at risk of developing diabetes.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27686165</pmid><doi>10.1186/s12916-016-0693-4</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Analysis Blood pressure Body mass index Care and treatment Cholesterol Cohort analysis Complications and side effects Cross-sectional studies Diabetes Glucose Health aspects Hormone replacement therapy Hyperthyroidism Hypothyroidism Immunoassay Insulin resistance Metabolism Pharmacy Questionnaires Thyroid diseases Thyrotropin Type 2 diabetes |
| title | Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study |
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