An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase† †Electronic supplementary information (ESI) available: Experimental and computational details. See DOI: 10.1039/c6cc03904a Click here for additional data file

Combined spectroscopic, kinetic and computational studies provide first evidence of a short-lived intermediate in the catalytic cycle of cysteine dioxygenase. Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic an...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2016-06, Vol.52 (57), p.8814-8817
Hauptverfasser:	Tchesnokov, E. P., Faponle, A. S., Davies, C. G., Quesne, M. G., Turner, R., Fellner, M., Souness, R. J., Wilbanks, S. M., de Visser, S. P., Jameson, G. N. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	8817
container_issue	57
container_start_page	8814
container_title	Chemical communications (Cambridge, England)
container_volume	52
creator	Tchesnokov, E. P. Faponle, A. S. Davies, C. G. Quesne, M. G. Turner, R. Fellner, M. Souness, R. J. Wilbanks, S. M. de Visser, S. P. Jameson, G. N. L.
description	Combined spectroscopic, kinetic and computational studies provide first evidence of a short-lived intermediate in the catalytic cycle of cysteine dioxygenase. Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm.
doi_str_mv	10.1039/c6cc03904a
format	Article
fullrecord	<record><control><sourceid>pubmedcentral</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5043143</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>pubmedcentral_primary_oai_pubmedcentral_nih_gov_5043143</sourcerecordid><originalsourceid>FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_50431433</originalsourceid><addsrcrecordid>eNqlUL1OwzAQthCIlp-FJ7gRhpakcfo3IKESRCeGMrBFV-fSGlw7Styq2foOvADP1tdg4VpgQIycZN1n33ff3WchLsKgHQbR4Fp1leIcSDwQzTDqylYs-8-HOxwPWr1Ixg1xUlUvAUcY949Fo9PrDHoylk3xcWtBl85uN29uXc-Ib9ZTuaBMoyfI3Q5Ctiy1nYGfEyj0aGqvFahaGQKXM6g8aUuQ6S8NrGi7eQc-iSHlWZ7p1bIoDC3IeixrnrKTRq-dhctkMr4CXKE2ODU0hGRdUKn3VANoM1BuUSz9ns0vGXmmVm2YEMHd43gIf38CRkarV5hTuTcBmGX6p50dQK4NnYmjHE1F59_5VNzcJ0-jh1axnLJrxfNLNGnBq_DKqUOd_q5YPU9nbpXGgYxCGUX_FvgETuydiA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase† †Electronic supplementary information (ESI) available: Experimental and computational details. See DOI: 10.1039/c6cc03904a Click here for additional data file</title><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><creator>Tchesnokov, E. P. ; Faponle, A. S. ; Davies, C. G. ; Quesne, M. G. ; Turner, R. ; Fellner, M. ; Souness, R. J. ; Wilbanks, S. M. ; de Visser, S. P. ; Jameson, G. N. L.</creator><creatorcontrib>Tchesnokov, E. P. ; Faponle, A. S. ; Davies, C. G. ; Quesne, M. G. ; Turner, R. ; Fellner, M. ; Souness, R. J. ; Wilbanks, S. M. ; de Visser, S. P. ; Jameson, G. N. L.</creatorcontrib><description>Combined spectroscopic, kinetic and computational studies provide first evidence of a short-lived intermediate in the catalytic cycle of cysteine dioxygenase. Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c6cc03904a</identifier><identifier>PMID: 27297454</identifier><language>eng</language><publisher>Royal Society of Chemistry</publisher><subject>Chemistry</subject><ispartof>Chemical communications (Cambridge, England), 2016-06, Vol.52 (57), p.8814-8817</ispartof><rights>This journal is © The Royal Society of Chemistry 2016 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Tchesnokov, E. P.</creatorcontrib><creatorcontrib>Faponle, A. S.</creatorcontrib><creatorcontrib>Davies, C. G.</creatorcontrib><creatorcontrib>Quesne, M. G.</creatorcontrib><creatorcontrib>Turner, R.</creatorcontrib><creatorcontrib>Fellner, M.</creatorcontrib><creatorcontrib>Souness, R. J.</creatorcontrib><creatorcontrib>Wilbanks, S. M.</creatorcontrib><creatorcontrib>de Visser, S. P.</creatorcontrib><creatorcontrib>Jameson, G. N. L.</creatorcontrib><title>An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase† †Electronic supplementary information (ESI) available: Experimental and computational details. See DOI: 10.1039/c6cc03904a Click here for additional data file</title><title>Chemical communications (Cambridge, England)</title><description>Combined spectroscopic, kinetic and computational studies provide first evidence of a short-lived intermediate in the catalytic cycle of cysteine dioxygenase. Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm.</description><subject>Chemistry</subject><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqlUL1OwzAQthCIlp-FJ7gRhpakcfo3IKESRCeGMrBFV-fSGlw7Styq2foOvADP1tdg4VpgQIycZN1n33ff3WchLsKgHQbR4Fp1leIcSDwQzTDqylYs-8-HOxwPWr1Ixg1xUlUvAUcY949Fo9PrDHoylk3xcWtBl85uN29uXc-Ib9ZTuaBMoyfI3Q5Ctiy1nYGfEyj0aGqvFahaGQKXM6g8aUuQ6S8NrGi7eQc-iSHlWZ7p1bIoDC3IeixrnrKTRq-dhctkMr4CXKE2ODU0hGRdUKn3VANoM1BuUSz9ns0vGXmmVm2YEMHd43gIf38CRkarV5hTuTcBmGX6p50dQK4NnYmjHE1F59_5VNzcJ0-jh1axnLJrxfNLNGnBq_DKqUOd_q5YPU9nbpXGgYxCGUX_FvgETuydiA</recordid><startdate>20160609</startdate><enddate>20160609</enddate><creator>Tchesnokov, E. P.</creator><creator>Faponle, A. S.</creator><creator>Davies, C. G.</creator><creator>Quesne, M. G.</creator><creator>Turner, R.</creator><creator>Fellner, M.</creator><creator>Souness, R. J.</creator><creator>Wilbanks, S. M.</creator><creator>de Visser, S. P.</creator><creator>Jameson, G. N. L.</creator><general>Royal Society of Chemistry</general><scope>5PM</scope></search><sort><creationdate>20160609</creationdate><title>An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase† †Electronic supplementary information (ESI) available: Experimental and computational details. See DOI: 10.1039/c6cc03904a Click here for additional data file</title><author>Tchesnokov, E. P. ; Faponle, A. S. ; Davies, C. G. ; Quesne, M. G. ; Turner, R. ; Fellner, M. ; Souness, R. J. ; Wilbanks, S. M. ; de Visser, S. P. ; Jameson, G. N. L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_50431433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tchesnokov, E. P.</creatorcontrib><creatorcontrib>Faponle, A. S.</creatorcontrib><creatorcontrib>Davies, C. G.</creatorcontrib><creatorcontrib>Quesne, M. G.</creatorcontrib><creatorcontrib>Turner, R.</creatorcontrib><creatorcontrib>Fellner, M.</creatorcontrib><creatorcontrib>Souness, R. J.</creatorcontrib><creatorcontrib>Wilbanks, S. M.</creatorcontrib><creatorcontrib>de Visser, S. P.</creatorcontrib><creatorcontrib>Jameson, G. N. L.</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical communications (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tchesnokov, E. P.</au><au>Faponle, A. S.</au><au>Davies, C. G.</au><au>Quesne, M. G.</au><au>Turner, R.</au><au>Fellner, M.</au><au>Souness, R. J.</au><au>Wilbanks, S. M.</au><au>de Visser, S. P.</au><au>Jameson, G. N. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase† †Electronic supplementary information (ESI) available: Experimental and computational details. See DOI: 10.1039/c6cc03904a Click here for additional data file</atitle><jtitle>Chemical communications (Cambridge, England)</jtitle><date>2016-06-09</date><risdate>2016</risdate><volume>52</volume><issue>57</issue><spage>8814</spage><epage>8817</epage><pages>8814-8817</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>Combined spectroscopic, kinetic and computational studies provide first evidence of a short-lived intermediate in the catalytic cycle of cysteine dioxygenase. Cysteine dioxygenase is a key enzyme in the breakdown of cysteine, but its mechanism remains controversial. A combination of spectroscopic and computational studies provides the first evidence of a short-lived intermediate in the catalytic cycle. The intermediate decays within 20 ms and has absorption maxima at 500 and 640 nm.</abstract><pub>Royal Society of Chemistry</pub><pmid>27297454</pmid><doi>10.1039/c6cc03904a</doi><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 1359-7345
ispartof	Chemical communications (Cambridge, England), 2016-06, Vol.52 (57), p.8814-8817
issn	1359-7345 1364-548X
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5043143
source	Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects	Chemistry
title	An iron–oxygen intermediate formed during the catalytic cycle of cysteine dioxygenase† †Electronic supplementary information (ESI) available: Experimental and computational details. See DOI: 10.1039/c6cc03904a Click here for additional data file
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T07%3A04%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmedcentral&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=An%20iron%E2%80%93oxygen%20intermediate%20formed%20during%20the%20catalytic%20cycle%20of%20cysteine%20dioxygenase%E2%80%A0%20%E2%80%A0Electronic%20supplementary%20information%20(ESI)%20available:%20Experimental%20and%20computational%20details.%20See%20DOI:%2010.1039/c6cc03904a%20Click%20here%20for%20additional%20data%20file&rft.jtitle=Chemical%20communications%20(Cambridge,%20England)&rft.au=Tchesnokov,%20E.%20P.&rft.date=2016-06-09&rft.volume=52&rft.issue=57&rft.spage=8814&rft.epage=8817&rft.pages=8814-8817&rft.issn=1359-7345&rft.eissn=1364-548X&rft_id=info:doi/10.1039/c6cc03904a&rft_dat=%3Cpubmedcentral%3Epubmedcentral_primary_oai_pubmedcentral_nih_gov_5043143%3C/pubmedcentral%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/27297454&rfr_iscdi=true