Identification of HRAS as cancer-promoting gene in gastric carcinoma cell aggressiveness

Identification of HRAS as cancer-promoting gene in gastric carcinoma cell aggressiveness

Gastric carcinoma is one of the most lethal malignancies of cancers and its prognosis remains dismal due to the paucity of effective therapeutic targets. Herein, we showed that HRAS is markedly up-regulated in gastric carcinoma. Prognostic analysis indicated that HRAS expression might be a prognosti...

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Veröffentlicht in:American journal of cancer research 2016-01, Vol.6 (9), p.1935-1948
Hauptverfasser: Wu, Xiao Yu, Liu, Wen Tao, Wu, Zhen Feng, Chen, Che, Liu, Jia Yun, Wu, Guan Nan, Yao, Xue Quan, Liu, Fu Kun, Li, Gang
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container_end_page 1948
container_issue 9
container_start_page 1935
container_title American journal of cancer research
container_volume 6
creator Wu, Xiao Yu
Liu, Wen Tao
Wu, Zhen Feng
Chen, Che
Liu, Jia Yun
Wu, Guan Nan
Yao, Xue Quan
Liu, Fu Kun
Li, Gang
description Gastric carcinoma is one of the most lethal malignancies of cancers and its prognosis remains dismal due to the paucity of effective therapeutic targets. Herein, we showed that HRAS is markedly up-regulated in gastric carcinoma. Prognostic analysis indicated that HRAS expression might be a prognostic indicator for the survival of patients with gastric carcinoma. Ectopic expression of HRAS in gastric carcinoma cells accelerated proliferation, migration, invasion, angiogenesis, and clone formation ability of gastric carcinoma cells in vitro. Furthermore, HRAS over-expressing significantly promoted the tumorigenicity of gastric carcinoma cells in vivo whereas silencing endogenous HRAS caused opposite outcomes. Moreover, we demonstrated that HRAS enhanced gastric carcinoma aggressiveness by activating VEGFA/PI3K/AKT pathway and Raf-1 signaling. Together, our results provide new evidence that HRAS overexpression promotes the progression of gastric carcinoma and might represent a novel therapeutic target for its treatment.
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title Identification of HRAS as cancer-promoting gene in gastric carcinoma cell aggressiveness
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