Pharmacokinetics and pharmacodynamics of mepolizumab, an anti-interleukin 5 monoclonal antibody, in healthy Japanese male subjects

Interleukin 5 (IL‐5) and eosinophils are thought to play an important role in the pathology of asthma. This study evaluated the pharmacokinetics, pharmacodynamics, safety, and tolerability of mepolizumab, a humanized anti‐IL5 IgG1 monoclonal antibody, in development for the treatment of severe eosin...

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Veröffentlicht in:	Clinical pharmacology in drug development 2016-03, Vol.5 (2), p.102-108
Hauptverfasser:	Tsukamoto, Naohiro, Takahashi, Naoki, Itoh, Hiroshi, Pouliquen, Isabelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Adult Anti-Asthmatic Agents - administration & dosage Anti-Asthmatic Agents - pharmacokinetics Anti-Asthmatic Agents - pharmacology anti-interleukin 5 Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - pharmacokinetics Antibodies, Monoclonal, Humanized - pharmacology Asian Continental Ancestry Group Asthma blood eosinophils Cytokines Dose-Response Relationship, Drug Eosinophils - drug effects Eosinophils - metabolism Half-Life Humans Interleukin-5 - immunology Male mepolizumab pharmacodynamics pharmacokinetics Single-Blind Method Time Factors Young Adult
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