Gelsolin-mediated activation of PI3K/Akt pathway is crucial for hepatocyte growth factor-induced cell scattering in gastric carcinoma

In gastric cancer (GC), the main subtypes (diffuse and intestinal types) differ in pathological characteristics, with diffuse GC exhibiting early disseminative and invasive behaviour. A distinctive feature of diffuse GC is loss of intercellular adhesion. Although widely attributed to mutations in th...

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Veröffentlicht in:	Oncotarget 2016-05, Vol.7 (18), p.25391-25407
Hauptverfasser:	Huang, Baohua, Deng, Shuo, Loo, Ser Yue, Datta, Arpita, Yap, Yan Lin, Yan, Benedict, Ooi, Chia Huey, Dinh, Thuy Duong, Zhuo, Jingli, Tochhawng, Lalchhandami, Gopinadhan, Suma, Jegadeesan, Tamilarasi, Tan, Patrick, Salto-Tellez, Manuel, Yong, Wei Peng, Soong, Richie, Yeoh, Khay Guan, Goh, Yaw Chong, Lobie, Peter E, Yang, Henry, Kumar, Alan Prem, Maciver, Sutherland K, So, Jimmy B Y, Yap, Celestial T
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD Cadherins - metabolism Carcinoma - metabolism Carcinoma - pathology Gelsolin - metabolism Hepatocyte Growth Factor - metabolism Humans Neoplasm Invasiveness - pathology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Research Paper Signal Transduction - physiology Stomach Neoplasms - metabolism Stomach Neoplasms - pathology
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